Results 71 to 80 of about 108,296 (296)

Identity and Congruence: The Ethics of Integrity in the Johannine Epistles (Chapter in Biblical Ethics and Application)

open access: yes, 2017
If the Johannine eagle soared above the earth, it did so with talons bared for the fight; and the last writings that were left show the eaglets tearing at each other for the possession of the nest.
Anderson, Paul N.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

A Bond Stronger Than Marriage: Discipleship in the Works of Christopher Isherwood

open access: yesPrague Journal of English Studies, 2019
This paper is concerned with Christopher Isherwood’s portrayal of his guru-disciple relationship with Swami Prabhavananda, situating it in the tradition of discipleship, which dates back to antiquity.
Latała Kinga
doaj   +1 more source

Discernment-Oriented Leadership in the Johannine Situation—Abiding in the Truth versus Lesser Alternatives (Chapter in Rethinking the Ethics of John: Implicit Ethics in the Johannine Writings)

open access: yes, 2012
Excerpt: Leadership within the Johannine situation has been approached from various angles, ranging from structures of leadership, to the location of Johannine Christianity with relation to other groups, to the identity/nonidentity of Johannine leaders.
Anderson, Paul N.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

श्रीअरविन्देन प्रकाशम् आनीता श्रीमद्भगवद्गीता

open access: yesPrachi Prajna, 2019
भगवद्गीतायाः विषयः सहस्रेभ्यः वर्षेभ्यः ज्ञानिभिः चर्चितः। तेषु विंशतेः शताब्देः एकः महान् योगी वर्तते श्रीअरविन्दः घोषः। महर्षिणा श्रीअरविन्देन स्वस्य "Essays on the Gita" ("गीतानिबन्धाः") नाम्नि पुस्तके भगवद्गीतायाः अध्यात्मस्य कानिचन महत्त्वपूर्णान ...
Mrs Ojasi Sukhatankar
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

The Community That Raymond Brown Left Behind: Reflections on the Johannine Dialectical Situation

open access: yes, 2013
Among the paradigm-making contributions in Johannine studies over the last half century, one of the most significant is the sketching of “the community of the Beloved Disciple” by Raymond E. Brown (Brown 1979). Extending beyond Johannine studies, Brown’s
Anderson, Paul N.
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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