Results 61 to 70 of about 45,126 (263)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats

Canadian Journal of Gastroenterology and Hepatology, 2020
Background. The incidence of diabetic gastroparesis (DGP) is mainly blamed to abnormity of interstitial cells of Cajal (ICCs). Autophagy could degrade damaged proteins and organelles to keep intracellular homeostasis, and it could directly influence ...
Xing Wei, Yaping Lin, Dongfeng Zhao, Xiaojuan Xiao, Qiao Chen, Siyi Chen, Yan Peng   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Uphold Fundamental Principles and Break New Ground and Work Persistently to Build a First-Class Forensic Medicine Discipline

Fayixue Zazhi
The construction of first-class universities and disciplines is a major strategic initiative of the Communist Party of China Central Committee and the State Council, and an important task for building a world-class higher education powerhouse.
LI Shu-jin, MA Chun-ling, CONG Bin
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Thoughts on the Development of Forensic Medicine Discipline Standing at a New Historical Starting Point

Fayixue Zazhi
The development of forensic medicine is crucial to the national welfare, people’s livelihood, social stability, and the construction of a Safe China. It plays an indispensable role in the comprehensive promotion of the rule of law.
LI Cheng-tao, CONG Bin
doaj   +1 more source

[First-Class Nursing Discipline Construction Spearheads the Cultivation of First-Class Talents]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Hu YJ, Li LL, Tian YL, Zhang FY, Liu HH, Qiu C, Li K.   +6 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Contemplation on Development of Traditional Chinese Medicine Rehabilitation Science

康复学报, 2017
Although the concept of Traditional Chinese Medicine Rehabilitation Science began in the 1980s, a lot of rehabilitation treatments were recorded on ancient classics of traditional Chinese medicine (TCM). For example, Huangdi Neijing emphasizes regulating
Xiaodong FENG
doaj  

Analysis of Vibration Transmission Path in Packaging System and Design of Teaching Experiment

Shock and Vibration
It is essential for realizing the most suitable product buffer packaging design to quantify the vibration transmission characteristics of the product packaging system.
Meilin Gong, Cong Lin
doaj   +1 more source