Results 111 to 120 of about 169,123 (346)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Questions on transitivity [PDF]
, 2010 This handout (it isn’t a paper) presents phenomena and questions, rather than conclusions, related to the concept of transitivity. The idea is to return to these questions at the end of the Workshop to see if we can have a clearer consensus about the ...
LaPolla, Randy J.
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
, 2008 The article puts forward a discourse-pragmatic approach to the notoriously evasive phenomena of contrastivity and emphasis. It is argued that occurrences of focus that are treated in terms of "contrastive focus", "kontrast" (Vallduví & Vilkuna 1998) or ...
Zimmermann, Malte
core
Relational Practice in Multilingual Peer Discourse: Talk as a Marker of Gender Identity
, 2021 Rabia Faiz +2 more
openalex +2 more sources
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Doctors and sheikhs: "Truths" in virginity discourse in Jordanian media [PDF]
, 2013 This article is concerned with the role Jordanian media play in circulating certain discourses on virginity, namely religious and medical discourses, which are presented as truths that ultimately maintain the conservative status quo with regards to ...
Mahadeen, Ebithal
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
THE FORMING OF NEW FUNCTIONS OF A DISCOURSE MARKER ZNACHIT IN THE SPOKEN DISCOURSE
Sovremennye Issledovaniâ Socialʹnyh ProblemBackground. In modern linguistics the phenomena of oral speech are actively studied, in particular the functioning of the discourse markers (units that play a crucial role in organizing the narrative and structuring the generated by the speaker discourse)
Diana D. Marchenyak +1 more
doaj +1 more source