Results 91 to 100 of about 732 (204)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Affective Configuration of the Public Problem of Depopulation: From Resignation to Obstinance

Communication & Society (Formerly Comunicación y Sociedad)
Participation in public problems involves diverse strategies, including the challenging and transformation of hegemonic affective configurations.
Vanesa Saiz-Echezarreta
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Naturalization, reciprocity and marks of marital violence: male defendants' perceptions

Revista Brasileira de Enfermagem
Objective: to analyze male criminals' perception about marital violence. Method: An exploratory, descriptive, qualitative study undertaken with 23 men who were criminally prosecuted for marital violence. A multimethod data collection was conducted, with
Gilvânia Patrícia do Nascimento Paixão, Alvaro Pereira, Nadirlene Pereira Gomes, Anderson Reis de Sousa, Fernanda Matheus Estrela, Ubirajara Ramos Pereira da Silva Filho, Igor Brasil de Araújo   +6 more
doaj   +1 more source

SURPRISING PEREGRINATIONS AND RELATIONSHIPS OF CONCEPTS. ON THE THOUGHT COLLECTIVE OF LUDWIK FLECK AND THE INTERPRETIVE COMMUNITY OF STANLEY FISH [PDF]

Filozofia i Nauka, 2019
The aim of the article is to compare the thought collective and the interpretive community, two surprisingly similar notions formulated independently by Ludwik Fleck and Stanley Fish.
Marzenna Cyzman
doaj  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Discourse homeostasis as a teacher’s tool: transition from personal concepts to expert terminology

Вестник Мининского университета
Introduction. Despite the declared transition to student-centered approach within the modern pedagogical paradigm, higher education continues to face a key contradiction between the declared commitment to dialogue and institutional inequality, as well as
O. A. Boginskaya
doaj   +1 more source

Discourse on “Collective Conventional Breaches” agreements. A new subject of social dialogue

, 2020
Cet article a pour objet l'analyse du contenu des accords de Ruptures Conventionnelles Collectives (RCC), nouveau dispositif juridique créé en 2017. Ceux-ci constituent un nouvel objet du dialogue social pour les parties prenantes. Dans le cadre d’une régulation conjointe, ces accords reposent sur des stratégies de négociation intégrative et de ...
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source