Results 81 to 90 of about 732 (204)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

From Human Sovereignty to Algorithmic Sovereignty

Politikon
Artificial intelligence amplifies contemporary crises by accelerating their dynamics, fragmenting democratic discourse, and weakening state control. This new technology is therefore a decisive factor in the uncontrollability of democracies, due to its ...
Laly Warnier
doaj   +1 more source

A GESTÃO ESCOLAR EM FOCO: REFLEXÕES PRELIMINARES

Colloquium Humanarum, 2015
In school management should be geared to meet the fundamental aspect, education. Essential for the human being, the subject of his own training. From this perspective, this paper has as main purpose to analyze the role of the manager and managing the ...
Elisangela Aparecida Bulla Ikeshoji, Adriana Aparecida de Lima Terçariol, Adriano Rodrigues Ruiz   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Virginie Despentes et les récits de la violence sexuelle : une déconstruction littéraire et féministe des rhétoriques de la racialisation

Genre, Sexualité et Société, 2012
In the  contemporary collective imagination, the suburbs [banlieues] epitomise masculine domination, contrasting with a society which thus appears free from sexism.
Virginie Sauzon
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Interface between conjugal violence and alcohol consumption by the partner

Revista Brasileira de Enfermagem
Objective: to analyze the discourse of women on the interface between marital violence and alcohol use by the partner. Method: qualitative exploratory research, based on the methodological reference of oral history.
Milca Ramaiane da Silva Carvalho, Jeane Freitas de Oliveira, Nadirlene Pereira Gomes, Mariana Matias Santos, Fernanda Matheus Estrela, Helenise Maria da Silva Duarte   +5 more
doaj   +1 more source

MOTIVATIONS, IMPORTANCE, CHALLENGES AND PERSPECTIVES OF SOCIAL CONTROL IN HEALTH

Cogitare Enfermagem, 2019
Purpose: To understand the motivations, importance, challenges and perspectives for acting as local health counselors in the Unified Health System.Method: A qualitative and descriptive study of the exploratory type conducted with 15 local health ...
Carlos Junglos, Felipa Rafaela Amadigi, Rosani Ramos Machado, Jacks Sorato   +3 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source