Results 61 to 70 of about 12,381 (255)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

THEMATIC AREA OF YOUTH DISCOURSE AS COLLECTIVE LINGUISTIC IDENTITY EXPLICATION

Вестник Кемеровского государственного университета, 2015
The article analyzes thematic area of youth discourse in printed edition. Modern "outbreak" of interest in a native speaker determines the relevance of the type of collective linguistic identity study (socio-cultural group) being the basic category for ...
M. G. Chabanenko
doaj  

Statements from women with cervical cancer in brachytherapy treatment: subsidies for nursing care

Revista de Enfermagem da Universidade Federal de Santa Maria, 2013
Objective: to know the perceptions of women with cervical cancer in brachytherapy treatment. Method: it is an exploratory and descriptive study of qualitative approach, with 16 women in brachytherapy treatment at specialized service of Florianópolis ...
Adriana Maria da Silva Rubini, José Luís Guedes dos Santos, Alacoque Lorenzini Erdmann, Luciana Martins da Rosa   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

PROGRESSIVE INTERPRETATION OF THE QUR'AN IN TAFSIR AT-TANWIR: MUHAMMADIYAH'S COLLECTIVE IDENTITY ON ENVIRONMENTAL ISSUES

QiST
Tafsir At-Tanwir, the progressive interpretations in it cannot be separated from Muhammadiyah's collective identity. The logical consequence of efforts to understand the interpretations in Tafsir At-Tanwir, directly or indirectly, needs to understand ...
Al Faiz Muhammad Rabbany Tarman, Arifah Cahyo Andini Suparmun, Isral Naska   +2 more
doaj   +1 more source

Subjects, Agents, or Collectives? The Discourse of Youth and Philosophy

Legon Journal of the Humanities, 2015
The present paper argues that the term "youth", which is traditionally used to refer both to young people of a certain age bracket and to a time of life between childhood and maturity has acquired distinctive yet contradictory meanings since the 19th century, and that the category of people, individuals, or persons that the concept describes or ...
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The inter and intra-collective circulation of knowledge on experimental activities in professional development and the training of chemistry teacher trainers [PDF]

Investigações em Ensino de Ciências, 2012
This study examined how the professional development and the training of Chemistry teacher trainers can contribute to learning on experimentation in Science/Chemistry teaching.
Fábio Peres Gonçalves, Carlos Alberto Marques   +1 more
doaj