Results 71 to 80 of about 732 (204)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2021 O trabalho analisa os discursos do sujeito coletivo agentes penitenciários do Conjunto Penal de Teixeira de Freitas acerca da educação e dos direitos humanos. Para tanto, foi adotada uma abordagem qualiquantitativa, tendo por base as metodologias do estudo de caso e do Discurso do Sujeito Coletivo (DSC), sendo utilizados os recursos metodológicos da ...
Sousa, Leonardo da Silva Carneiro +1 more
openaire +1 more source
REVISTA CIÊNCIAS EM SAÚDE, 1970 Objetivos: identificar as características pessoais e acadêmicas dos alunos de enfermagem e medicina em seus últimos períodos escolares; conhecer os significados de cuidados paliativos e identificar os sentimentos desses acadêmicos em relação aos pacientes com necessidades de cuidados paliativos.
dos Reis, Marcela Weitzembaur +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Past and Future in the Construction of Communal Identity: Collective Memory and Mythical Narratives
Skandinaviske Sprogstudier, 2015 This article relates to the question of whether or to what extent identity is wholly constructed through language by engaging in a discussion of how the use of the past enters into the construction of communal identity.
Christoffer Kølvraa
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Teacher practice reports: the collective subject discourse unveiling their contributions
, 2017 As sessões de apresentação de relatos de prática já fazem parte da programação dos Seminários Web Currículo, promovidos pelo Programa de Pós-Graduação em Educação: Currículo da Pontifícia Universidade Católica de São Paulo (PUC-SP). Visando a compreender as contribuições das apresentações de tais práticas, sob a perspectiva dos participantes nas ...
Gonçalves, Lina Maria +2 more
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Saúde e Sociedade, 2003 O presente artigo traz uma avaliação da satisfação dos alunos dos cursos de especialização "Capacitação e Desenvolvimento de Recursos Humanos em Saúde- CADRHU-2002", que foram oferecidos pelo convênio firmado entre a Secretaria de Estado da Saúde e Faculdade de Saúde Pública/USP.
Ana Maria Cavalcanti Lefevre +2 more
openaire +2 more sources