Results 71 to 80 of about 15,467,312 (299)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A 90.9 dB SNDR 95.3 dB DR Audio Delta–Sigma Modulator with FIA-Assisted OTA

open access: yesSensors
This paper presents a low-power, high-gain integrator design that uses a cascode operational transconductance amplifier (OTA) with floating inverter–amplifier (FIA) assistance. Compared to a traditional cascode, the proposed integrator can achieve a gain
Gongxing Huang, Cong Wei, Rongshan Wei
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Discrete element method to simulate continuous material by using the cohesive beam model [PDF]

open access: yes, 2012
The mechanical behavior of materials is usually simulated by the continuous mechanics approach. However, simulation of non-continuous phenomena like multi fracturing is not well adapted to a continuous description.
Jean-luc Charles   +8 more
core   +1 more source

Stability of convex linear combinations of continuous-time and discrete-time linear systems [PDF]

open access: yesArchives of Control Sciences
The asymptotic stability of the convex linear combination of continuous-time and discretetime linear systems is considered. Using the Gershgorin theorem it is shown that the convex linear combination of the linear asymptotically stable continuous-time ...
Tadeusz Kaczorek
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Discrete-time recurrent neural networks with time-varying delays: Exponential stability analysis [PDF]

open access: yes, 2007
This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2007 Elsevier LtdThis Letter is concerned with the analysis problem of exponential stability for a class of discrete-time ...
Liu, Y, Liu, X, Wang, Z, Serrano, A
core   +1 more source

Discrete Time q-TASEPs [PDF]

open access: yesInternational Mathematics Research Notices, 2013
We introduce two new exactly solvable (stochastic) interacting particle systems which are discrete time versions of q-TASEP. We call these geometric and Bernoulli discrete time q-TASEP. We obtain concise formulas for expectations of a large enough class of observables of the systems to completely characterize their fixed time distributions when started
Borodin, Alexei, Corwin, Ivan
openaire   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Integrated fault estimation and accommodation design for discrete-time Takagi-Sugeno fuzzy systems with actuator faults [PDF]

open access: yes, 2011
This paper addresses the problem of integrated robust fault estimation (FE) and accommodation for discrete-time Takagi–Sugeno (T–S) fuzzy systems. First, a multiconstrained reduced-order FE observer (RFEO) is proposed to achieve FE for discrete-time ...
Zhang, Ke   +8 more
core   +1 more source

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