Results 31 to 40 of about 1,343,745 (312)

Discrete choice experiments: An overview on constructing D-optimal and near-optimal choice sets

open access: yesHeliyon, 2023
Discrete choice experiments (DCEs) are frequently used to estimate and forecast the behavior of an individual's choice. DCEs are based on stated preference; therefore, underlying experimental designs are required for this type of study.
Abdulrahman S. Alamri   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Incorporating human dimensions objectives into waterfowl habitat planning and delivery

open access: yesWildlife Society Bulletin, 2017
The 2012 revision of the North American Waterfowl Management Plan (NAWMP) explicitly recognized the need to increase recruitment and retention of waterfowl hunters, birdwatchers, and other conservationists to maintain support for wetland conservation ...
Patrick K. Devers   +4 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The role of location in residential location choice models: a review of literature

open access: yesJournal of Transport and Land Use, 2014
Geospatial data available to researchers has increased tremendously over the last several decades, opening up opportunities to define residential location in multiple ways.
Patrick M. Schirmer   +2 more
doaj   +1 more source

Patients’ Preferences and Willingness to Pay for Solid Forms of Oral Medications—Results of the Discrete Choice Experiment in Polish Outpatients

open access: yesPharmaceutics, 2020
Purpose: Personal preferences play an important role in the patients’ decision process whether to adhere to treatment, or not. The purpose of this study is to assess Polish outpatients’ preferences for solid forms of oral medications across ...
Marta Kurczewska-Michalak   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Dense-choice Counter Machines revisited

open access: yes, 2009
This paper clarifies the picture about Dense-choice Counter Machines, which have been less studied than (discrete) Counter Machines. We revisit the definition of "Dense Counter Machines" so that it now extends (discrete) Counter Machines, and we provide ...
Bouchy, Florent   +2 more
core   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Stimulating agritourism loyalty in the Mid-Atlantic states of the USA

open access: yesTourism
Agritourism as a niche tourism market has become an alternative income-generating sector for conventional farmers that focus on both production and marketing.
Rahmiye Figen Ceylan   +3 more
doaj   +1 more source

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