Results 51 to 60 of about 932,059 (284)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Performance of Monotonic Pile Penetration in Sand: Model Test and DEM Simulation

Buildings
By integrating laboratory tests and three-dimensional discrete element methods, this research extensively explores the macroscopic and microscopic mechanisms of static pile penetration in standard sand.
Jianxue Feng, Ruiqi Luo, Xiaoyu Dong, Xiaoyong Zhang, Quan Shen   +4 more
doaj   +1 more source

Allen-Cahn and Cahn-Hilliard variational inequalities solved with Optimization Techniques [PDF]

, 2010
Parabolic variational inequalities of Allen-Cahn and Cahn- Hilliard type are solved using methods involving constrained optimization. Time discrete variants are formulated with the help of Lagrange multipliers for local and non-local equality and ...
Blank, Luise, Butz, Martin, Garcke, Harald, Sarbu, Lavinia, Styles, Vanessa   +4 more
core  

A simplicial gauge theory

, 2011
We provide an action for gauge theories discretized on simplicial meshes, inspired by finite element methods. The action is discretely gauge invariant and we give a proof of consistency. A discrete Noether's theorem that can be applied to our setting, is
Bossavit A., Ciarlet P. G., Dodziuk J., Haugazeau Y., Kobayashi S., Mansfield E. L., Mansfield E. L., Prasolov V. V., Raviart P. A., Rothe H. J., Snorre H. Christiansen, Strang G., Tore G. Halvorsen, Weinberg S., Weinberg S., Yee K. S.   +15 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Certain Discrete Element Methods in Problems of Fracture Mechanics

Acta Polytechnica, 2002
In this paper two discrete element methods (DEM) are discussed. The free hexagon element method is considered a powerful discrete element method, which is broadly used in mechanics of granular media.
P. P. Procházka, M. G. Kugblenu
doaj  

Discrete maximal parabolic regularity for Galerkin finite element methods for non-autonomous parabolic problem s

, 2017
The main goal of the paper is to establish time semidiscrete and space-time fully discrete maximal parabolic regularity for the lowest order time discontinuous Galerkin solution of linear parabolic equations with time-dependent coefficients.
Leykekhman, Dmitriy, Vexler, Boris
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Fractional Crank-Nicolson-Galerkin Finite Element Methods for Nonlinear Time Fractional Parabolic Problems with Time Delay

Journal of Function Spaces, 2021
A linearized numerical scheme is proposed to solve the nonlinear time-fractional parabolic problems with time delay. The scheme is based on the standard Galerkin finite element method in the spatial direction, the fractional Crank-Nicolson method, and ...
Lili Li, Mianfu She, Yuanling Niu
doaj   +1 more source

Unified Framework for Finite Element Assembly

, 2009
At the heart of any finite element simulation is the assembly of matrices and vectors from discrete variational forms. We propose a general interface between problem-specific and general-purpose components of finite element programs.
Alnæs, Martin Sandve, Langtangen, Hans Petter, Logg, Anders, Mardal, Kent-Andre, Skavhaug, Ola   +4 more
core   +1 more source