Results 51 to 60 of about 1,409,098 (301)

Application of the Discrete Element Method for Manufacturing Process Simulation in the Pharmaceutical Industry

Pharmaceutics, 2019
Process simulation using mathematical modeling tools is becoming more common in the pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can enhance process understanding, reduce experimentation cost and improve product ...
S. Yeom, Eun-Sol Ha, Min‐Soo Kim, S. Jeong, Sung-Joo Hwang, D. Choi   +5 more
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Performance of Monotonic Pile Penetration in Sand: Model Test and DEM Simulation

Buildings
By integrating laboratory tests and three-dimensional discrete element methods, this research extensively explores the macroscopic and microscopic mechanisms of static pile penetration in standard sand.
Jianxue Feng, Ruiqi Luo, Xiaoyu Dong, Xiaoyong Zhang, Quan Shen   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Certain Discrete Element Methods in Problems of Fracture Mechanics

Acta Polytechnica, 2002
In this paper two discrete element methods (DEM) are discussed. The free hexagon element method is considered a powerful discrete element method, which is broadly used in mechanics of granular media.
P. P. Procházka, M. G. Kugblenu
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Methodologies for Evaluation of Foreign Object Migration Within Aircraft Fuel Tank

Machines
Foreign Objects (FO) within an aircraft fuel tank present a serious risk of damage and possible catastrophic loss of the aircraft. As such, aircraft manufacturers place great emphasis on the thorough inspection of fuel tanks before they are closed and ...
Christopher Lee Colaw, Behzad Parvaresh, Luz Bugarin, Asahel Marinelarena-Diaz, Ricardo Chacon, Daniela Garcia, Bill Tseng, Yirong Lin   +7 more
doaj   +1 more source

Fractional Crank-Nicolson-Galerkin Finite Element Methods for Nonlinear Time Fractional Parabolic Problems with Time Delay

Journal of Function Spaces, 2021
A linearized numerical scheme is proposed to solve the nonlinear time-fractional parabolic problems with time delay. The scheme is based on the standard Galerkin finite element method in the spatial direction, the fractional Crank-Nicolson method, and ...
Lili Li, Mianfu She, Yuanling Niu
doaj   +1 more source

A Fully Discrete Evolving Surface Finite Element Method [PDF]

SIAM Journal on Numerical Analysis, 2012
In this paper we consider a time discrete evolving surface finite element method for the advection and diffusion of a conserved scalar quantity on a moving surface. In earlier papers using a suitable variational formulation in time dependent Sobolev space we proposed and analyzed a finite element method using surface finite elements on evolving ...
Gerhard Dziuk, Charles M. Elliott
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source