Results 61 to 70 of about 932,059 (284)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Methodologies for Evaluation of Foreign Object Migration Within Aircraft Fuel Tank

Machines
Foreign Objects (FO) within an aircraft fuel tank present a serious risk of damage and possible catastrophic loss of the aircraft. As such, aircraft manufacturers place great emphasis on the thorough inspection of fuel tanks before they are closed and ...
Christopher Lee Colaw, Behzad Parvaresh, Luz Bugarin, Asahel Marinelarena-Diaz, Ricardo Chacon, Daniela Garcia, Bill Tseng, Yirong Lin   +7 more
doaj   +1 more source

Tutorial on the fragmentation of the railway ballast particles and calibration methods in discrete element modelling

Acta Technica Jaurinensis, 2021
This paper presents a short literature review related to the fragmentation of the railway crushed ballast particles. With the help of the processed articles with the main topic of discrete element modelling (DEM) we aim to provide some insight into the ...
Erika Juhász, Szabolcs Fischer
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Computational mechanics in science, applications and teaching [PDF]

Theoretical and Applied Mechanics, 2013
We express our opinion about the role of Computational Mechanics (CM) in science, applications and education. The presented thoughts rely on our experience gained by working over decades (first author in particular) in the field of CM. First, as
Kojić M., Filipović N.
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Comparative Analysis of Finite Element and Discrete Element Methods for the Deformation and Failure of Embankment Slope

Buildings
The finite element method (FEM) and discrete element method (DEM) have been widely applied to analyze the deformation and failure processes of embankment slopes.
Jian Gong, Yongwei Li, Yangqing Liu, Qiaoming Guo, Haibin Ding, Lihua Li, Yu Huang, Weiwei Chen   +7 more
doaj   +1 more source

Discrete Element Modeling of the Seismic Behavior of Masonry Construction

Buildings, 2019
Discrete element models are a powerful tool for the analysis of masonry, given their ability to represent the discontinuous nature of these structures, and to simulate the most common deformation and failure modes.
José V. Lemos
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Discrete Element Simulation and Monitoring Analysis of Different Construction Methods of the Shallow Buried Bias Tunnel

Advances in Civil Engineering, 2022
Affected by the bias stress, the mechanical properties of shallow buried bias tunnel construction are complex. The influence of different construction methods on the stability of the portal section of the shallow buried bias tunnel has received ...
Chenyu Ge, Liping Su, Lin Wang, Shuo Xu, Pengqiang Yu   +4 more
doaj   +1 more source