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Computational mechanics in science, applications and teaching [PDF]
Theoretical and Applied Mechanics, 2013 We express our opinion about the role of Computational Mechanics (CM) in science, applications and education. The presented thoughts rely on our experience gained by working over decades (first author in particular) in the field of CM. First, as
Kojić M., Filipović N.
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Acta Technica Jaurinensis, 2021 This paper presents a short literature review related to the fragmentation of the railway crushed ballast particles. With the help of the processed articles with the main topic of discrete element modelling (DEM) we aim to provide some insight into the ...
Erika Juhász, Szabolcs Fischer
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Dual Virtual Element Method for Discrete Fractures Networks [PDF]
SIAM Journal on Scientific Computing, 2018 Discrete fracture networks is a key ingredient in the simulation of physical processes which involve fluid flow in the underground, when the surrounding rock matrix is considered impervious. In this paper we present two different models to compute the pressure field and Darcy velocity in the system.
Fumagalli A., Keilegavlen E.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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BuildingsThe finite element method (FEM) and discrete element method (DEM) have been widely applied to analyze the deformation and failure processes of embankment slopes.
Jian Gong +7 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
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Advances in Civil Engineering, 2022 Affected by the bias stress, the mechanical properties of shallow buried bias tunnel construction are complex. The influence of different construction methods on the stability of the portal section of the shallow buried bias tunnel has received ...
Chenyu Ge +4 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
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Application of Discrete Element Methods to the Problem of Rock Bumps
Acta Polytechnica, 2002 This paper is a continuation of a previous paper by the authors. Applications of two discrete element methods (DEM) to several fields of geotechnics are discussed.
P. P. Procházka, M. G. Kugblenu
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