Results 111 to 120 of about 5,142,656 (331)

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible. [PDF]

, 2018
To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1-/-) mouse model of Fragile X syndrome.
A Contractor, A Estes, A Mullard, Aditi Newadkar, Anubhuti Goel, B Zupan, Barbara Todisco, BN Armbruster, BV Atallah, C He, CA Runyan, Carlos Portera-Cailliau, CD Harvey, CE Robertson, CM Niell, Craig A. Erickson, CS Kogan, CS Kogan, CX He, Daniel A. Cantu, Diego de Alba, Ernest Pedapati, F Farzin, G Fata La, Gunvant R. Chaudhari, HA Zariwala, HK Kato, IS Knoth, J Akerboom, J Poort, Janna Guilfoyle, JC Cottam, JJ LeBlanc, JM Pakan, JP Hamm, JT Gonçalves, K Juczewski, K Plaisted, L Pinto, Lauren M. Schmitt, M Dipoppa, M Rifé, MT Arnett, Nazim Kourdougli, PJ Mineault, SB Hofer, SH Lee, SR Hooper, TA Pologruto, The Dutch-Belgian Fragile X Consortium., TW Chen, Y Gonchar, Y Zhang, ZV Guo   +53 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Human Rights in the Heartland: An Assessment of Social, Economic, Civil, and Political Rights in the Midwest [PDF]

, 2005
This report measures human rights progress in the heart of the United States. In this compilation, eight Midwestern states are evaluated on a freedom index, providing a comparative snapshot of local commitments to civil, political, social, and economic ...
Amy Rynell, Curtis Jones
core  

Optimal Population Coding, Revisited [PDF]

, 2011
Cortical circuits perform the computations underlying rapid perceptual decisions within a few dozen milliseconds with each neuron emitting only a few spikes.
Alexander S. Ecker, Andreas S. Tolias, Matthias Bethge, Philipp Berens, Sebastian Gerwinn   +4 more
core   +2 more sources

Assessment of differential item functioning in the experiences of discrimination index: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

American Journal of Epidemiology, 2011
The psychometric properties of instruments used to measure self-reported experiences of discrimination in epidemiologic studies are rarely assessed, especially regarding construct validity.
T. Cunningham, L. Berkman, S. Gortmaker, C. Kiefe, D. Jacobs, T. Seeman, I. Kawachi   +6 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Fine-grained nociceptive maps in primary somatosensory cortex [PDF]

, 2012
Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
,, Haggard, P, Iannetti, GD, Longo, MR, Mancini, F, Sereno, MI   +5 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Düzce Üniversitesi Tıp Fakültesi Öğrencilerine Uygulanan Sınavlarda Soruların Geçerlik ve Güvenirlik Analizi

Düzce Tıp Fakültesi Dergisi, 2018
Amaç: Bu araştırmanın amacı Düzce Üniversitesi Tıp Fakültesi Dönem I, Dönem II ve Dönem III öğrencilerine uygulanan sınav sorularının geçerlik ve güvenirlik analizlerini yapmaktır.Gereç ve Yöntemler: Düzce Üniversitesi Tıp Fakültesi Öğrenci İşlerinden ...
Handan ANKARALI, Şengül CANGÜR, Mehmet Ali SUNGUR, Safinaz ATAOĞLU   +3 more
doaj  

The polytomous discrimination index for prediction involving multistate processes under intermittent observation. [PDF]

Stat Med, 2022
Jiang S, Cook RJ.
europepmc   +1 more source