Results 141 to 150 of about 12,421,057 (398)
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
The Lancet, 2020 Christopher J L Aleksandr Y Peng Cristiana Kaja M Mohsen Foad Murray Aravkin Zheng Abbafati Abbas Abbasi-Kangeva, C. Murray, A. Aravkin, P. Zheng, C. Abbafati, K. Abbas, M. Abbasi-Kangevari, F. Abd-Allah, A. Abdelalim, M. Abdollahi, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Hassan Abolhassani, Victor Aboyans, Lucas Guimarães Abreu, Michael R. M. Abrigo, Ahmed Abualhasan, L. Abu-Raddad, A. Abushouk, M. Adabi, Victor Adekanmbi, A. Adeoye, O. Adetokunboh, Davoud Adham, S. Advani, Gina Agarwal, S. K. Aghamir, Anurag Agrawal, Tauseef Ahmad, K. Ahmadi, Mehdi Ahmadi, H. Ahmadieh, M. Ahmed, T. Akalu, R. Akinyemi, T. Akinyemiju, B. Akombi, C. Akunna, Fares Alahdab, Z. Al-Aly, K. Alam, Samiah Alam, Tahiya Alam, Fahad Mashhour Alanezi, Turki M. Alanzi, B. Alemu, K. Alhabib, Muhammad Ali, Saqib Ali, G. Alicandro, C. Alinia, V. Alipour, H. Alizade, S. Aljunid, François Alla, Peter Allebeck, A. Almasi-Hashiani, Hesham M Al-Mekhlafi, Jordi Alonso, K. Altirkawi, Mostafa Amini-Rarani, Fatemeh Amiri, D. Amugsi, R. Ancuceanu, Deanna Anderlini, Jason A Anderson, C. Andrei, Tudorel Andrei, Colin Angus, Mina Anjomshoa, F. Ansari, Alireza Ansari-Moghaddam, I. Antonazzo, C. Antonio, Catherine M. Antony, E. Antriyandarti, Davood Anvari, R. Anwer, Seth Christopher Yaw Appiah, J. Arabloo, M. Arab-Zozani, F. Ariani, Bahram Armoon, J. Ärnlöv, A. Arzani, Mehran Asadi-Aliabadi, A. Asadi-Pooya, Charlie Ashbaugh, Michael Assmus, Z. Atafar, Desta Debalkie Atnafu, Maha Moh’d Wahbi Atout, F. Ausloos, M. Ausloos, B. P. Ayala Quintanilla, Getinet Ayano, M. Ayanore, S. Azari, G. Azarian, Z. N. Azene, A. Badawi, A. Badiye, M. Bahrami, M. Bakhshaei, A. Bakhtiari, Shankar M. Bakkannavar, Alberto Baldasseroni, Kylie Ball, S. Ballew, Daniela Balzi, Maciej Banach, Srikanta K Banerjee, Agegnehu Bante, A. G. Baraki, S. Barker-Collo, T. Bärnighausen, L. Barrero, Celine M Barthelemy, Lingkan Barua, Sanjay Basu, B. Baune, M. Bayati, Jacob S. Becker, Neeraj Bedi, Ettore Beghi, Y. Béjot, M. L. Bell, F. Bennitt, I. Benseñor, Kidanemaryam Berhe, Adam E. Berman, A. Bhagavathula, R. Bhageerathy, N. Bhala, Dinesh Bhandari, Krittika Bhattacharyya, Z. Bhutta, A. Bijani, B. Bikbov, M. B. Bin Sayeed, A. Biondi, Binyam Minuye Birihane, C. Bisignano, R. Biswas, Helen Bitew, S. Bohlouli, Mehdi Bohluli, Alexandra S. Boon-Dooley, Guilherme Borges, A. Borzì, S. Borzouei, C. Bosetti, S. Boufous, D. Braithwaite, N. Breitborde, S. Breitner, H. Brenner, P. Briant, A. Briko, N. Briko, Gabrielle Britton, Dana Bryazka, Blair R Bumgarner, K. Burkart, R. Burnett, Sharath Burugina Nagaraja, Z. Butt, F. L. Caetano dos Santos, Leah E Cahill, L. Cámera, Ismael Campos-Nonato, Rosario Cárdenas, Giulia Carreras, J. Carrero, F. Carvalho, J. Castaldelli-Maia, C. Castañeda-Orjuela, G. Castelpietra, Franz Castro, K. Causey, Christopher R. Cederroth, Kelly M. Cercy, Ester Cerin, J. Chandan, Kai-Lan Chang, F. Charlson, Vijay Kumar Chattu, S. Chaturvedi, N. Cherbuin, Odgerel Chimed-Ochir, D. Y. Cho, J. Choi, H. Christensen, D. Chu, Michael T Chung, Sheng-Chia Chung, F. Cicuttini, Liliana G. Ciobanu, Massimo Cirillo, T. K. D. Classen, Aaron J. Cohen, K. Compton, Owen R. Cooper, V. M. Costa, Ewerton Cousin, R. Cowden, Di H Cross, Jessica A Cruz, Saad M A Dahlawi, Albertino Damasceno, G. Damiani, L. Dandona, R. Dandona, W. J. Dangel, A. Danielsson, P. Dargan, A. Darwesh, A. Daryani, Jai K Das, R. Das Gupta, J. D. das Neves, C. Dávila-Cervantes, D. Davițoiu, Diego De Leo, L. Degenhardt, Marissa N Delang, R. Dellavalle, F. M. Demeke, Gebre Teklemariam Demoz, D. Demsie, E. Denova-Gutiérrez, Nikolaos Dervenis, G. Dhungana, M. Dianatinasab, D. Dias da Silva, Daniel Diaz, Z. S. Dibaji Forooshani, S. Djalalinia, H. Do, K. Dokova, Fariba Dorostkar, L. Doshmangir, T. Driscoll, B. B. Duncan, A. Durães, Arielle Eagan, D. Edvardsson, Nevine M. El Nahas, Iman El Sayed, M. El Tantawi, I. Elbarazi, I. Elgendy, S. El-Jaafary, I. Elyazar, Sophia Emmons-Bell, H. Erskine, S. Eskandarieh, S. Esmaeilnejad, Alireza Esteghamati, Kara Estep, A. Etemadi, Atkilt Esaiyas Etisso, J. Fanzo, Mohammad Farahmand, Mohammad Fareed, R. Faridnia, Andrea Farioli, Andre Faro, M. Faruque, F. Farzadfar, N. Fattahi, Mehdi Fazlzadeh, Valery L. Feigin, Rachel Feldman, S. Fereshtehnejad, Eduarda Fernandes, Giannina Ferrara, A. Ferrari, Manuela L Ferreira, I. Filip, Florian Fischer, James L Fisher, L. Flor, N. Foigt, M. Foláyan, A. Fomenkov, Lisa M. Force, M. Foroutan, R. C. Franklin, Marisa Freitas, Weijia Fu, Takeshi Fukumoto, João M. Furtado, Mohamed M Gad, E. Gakidou, Silvano Gallus, A. García-Basteiro, William M Gardner, Biniyam Sahiledengle Geberemariyam, Assefa Ayalew Ayalew Gebreslassie, A. Geremew, Anna Gershberg Hayoon, P. Gething, Maryam Ghadimi, K. Ghadiri, F. Ghaffarifar, Mansour Ghafourifard, F. Ghamari, A. Ghashghaee, H. Ghiasvand, N. Ghith, A. Gholamian, Rakesh Ghosh, P. Gill, T. Ginindza, G. Giussani, E. Gnedovskaya, Salime Goharinezhad, S. Gopalani, G. Gorini, H. Goudarzi, A. Goulart, Felix Greaves, Michale Grivna, Giuseppe Grosso, M. I. Gubari, H. Gugnani, R. Guimarães, Rashid Abdi Guled, Gaorui Guo, Yuming Guo, R. Gupta, Tarun Gupta, Beatrix Haddock, N. Hafezi-Nejad, Abdul Hafiz, Arvin Haj-Mirzaian, A. Haj-Mirzaian, Brian J. Hall, Iman Halvaei, R. Hamadeh, S. Hamidi, M. Hammer, Graeme J. Hankey, H. Haririan, J. Haro, Ahmed I Hasaballah, M. Hasan, E. Hasanpoor, Abdiwahab Hashi, S. Hassanipour, H. Hassankhani, Rasmus J. Havmoeller, Simon Iain Hay, Khezar Hayat, G. Heidari, R. Heidari-Soureshjani, Hannah Henrikson, Molly E Herbert, C. Herteliu, F. Heydarpour, T. Hird, Hans W. Hoek, R. Holla, Praveen Hoogar, H. Hosgood, Naznin Hossain, M. Hosseini, M. Hosseinzadeh, M. Hostiuc, S. Hostiuc, Mowafa J Househ, M. Hsairi, V. C. Hsieh, Guoqing Hu, Kejia Hu, Tanvir M. Huda, A. Humayun, Chantal K Huynh, Bing-Fang Hwang, Vincent C Iannucci, S. E. Ibitoye, Nayu Ikeda, K. Ikuta, O S Ilesanmi, Irena M. Ilic, Milena D. Ilic, L. Inbaraj, Helen Ippolito, Usman Iqbal, S. Irvani, C. Irvine, M. M. Islam, Sheikh Mohammed Shariful Islam, Hiroyasu Iso, Rebecca Q Ivers, C. C. Iwu, C. Iwu, I. Iyamu, J. Jaafari, K. Jacobsen, Hussain Jafari, M. Jafarinia, M. Jahani, Mihajlo Jakovljevic, F. Jalilian, S. James, H. Janjani, Tahereh Javaheri, Javad Javidnia, P. Jeemon, E. Jenabi, R. P. Jha, Vivekanand Jha, John S Ji, Lars Johansson, Oommen John, Y. John-Akinola, C. Johnson, J. Jonas, F. Joukar, J. Jozwiak, M. Jürisson, Alia Kabir, Zubair Kabir, H. Kalani, Rizwan Kalani, Leila R. Kalankesh, R. Kalhor, T. Kanchan, Neeti Kapoor, B. Karami Matin, André Karch, M. Karim, G. Kassa, S. Katikireddi, G. Kayode, Ali Kazemi Karyani, P. Keiyoro, Cathleen Keller, L. Kemmer, Parkes Kendrick, Nauman Khalid, M. Khammarnia, E. Khan, Maseer Khan, Khaled Khatab, M. Khater, M. Khatib, M. Khayamzadeh, Salman Khazaei, C. Kieling, Y. Kim, R. Kimokoti, A. Kisa, S. Kisa, Mika Kivimäki, Luke D. Knibbs, A. Knudsen, Jonathan M Kocarnik, S. Kochhar, Jacek A. Kopec, V. A. Korshunov, P. Koul, Ai Koyanagi, Moritz U. G. Kraemer, K. Krishan, Kristopher J. Krohn, H. Kromhout, Barthelemy Kuate Defo, G. Kumar, Vivek Kumar, O. Kurmi, Dian Kusuma, C. La Vecchia, Ben Lacey, D. Lal, R. Lalloo, T. Lallukka, Faris Lami, I. Landires, Justin J. Lang, S. Langan, Anders O. Larsson, Savita Lasrado, P. Lauriola, J. Lazarus, P. H. Lee, Shaun Wen Huey Lee, K. E. LeGrand, J. Leigh, Matilde Leonardi, H. Lescinsky, Janni Leung, Miriam Levi, Shanshan Li, Lee-Ling Lim, S. Linn, Shiwei Liu, Simin Liu +499 moresemanticscholar +1 more sourceInhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski +7 morewiley +1 more sourceGlobal, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
The Lancet, 2020 K. Rudd, Sarah C Johnson, Kareha M Agesa, K. Shackelford, Derrick Tsoi, Daniel R. Kievlan, D. Colombara, K. Ikuta, N. Kissoon, S. Finfer, C. Fleischmann-Struzek, F. Machado, K. Reinhart, K. Rowan, C. Seymour, Scott Watson, Eoin T. West, Fatima Marinho, Simon Iain Hay, R. Lozano, A. D. Lopez, D. Angus, C. Murray, M. Naghavi +23 moresemanticscholar +1 more sourcePARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer +21 morewiley +1 more sourceCharacterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane +9 morewiley +1 more sourceBridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme +8 morewiley +1 more sourceAdenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski +14 morewiley +1 more sourceInvestigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov +10 morewiley +1 more source
