Results 161 to 170 of about 12,421,057 (398)
PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu +13 morewiley +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourceThe burden of Alzheimer's disease
The International Journal of Neuropsychopharmacology, 2000 Alzheimer's disease (AD) imposes a severe burden upon patients and their carers. In particular, family carers of AD patients face extreme hardship and distress that represents a major but often hidden burden on healthcare systems. Carers often experience clinically significant alterations in physical and mental health, particularly depression. A number openaire +2 more sourcesPatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceGlobal, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet, 2018 Spencer L Degu Kalkidan Hassen Solomon M Cristiana Nooshin James Abate Abate Abay Abbafati Abbasi Abbastabar , S. James, D. Abate, K. H. Abate, Solomon M Abay, C. Abbafati, Nooshin Abbasi, H. Abbastabar, F. Abd-Allah, Jemal Abdela, A. Abdelalim, Ibrahim Abdollahpour, R. Abdulkader, Zegeye Abebe, S. Abera, O. Abil, H. Abraha, L. Abu-Raddad, Niveen M. E. Abu-Rmeileh, Manfred Mario Kokou Accrombessi, Dilaram Acharya, Pawan Acharya, Ilana N. Ackerman, A. A. Adamu, O. Adebayo, Victor Adekanmbi, O. Adetokunboh, Mina G. Adib, J. C. Adsuar, K. Afanvi, Mohsen Afarideh, A. Afshin, Gina Agarwal, Kareha M Agesa, Rakesh Aggarwal, S. Aghayan, S. Agrawal, Alireza Ahmadi, Mehdi Ahmadi, H. Ahmadieh, M. Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Tomi F Akinyemiju, N. Akseer, Z. Al-Aly, A. Al-Eyadhy, Hesham M Al-Mekhlafi, R. Al-Raddadi, Fares Alahdab, K. Alam, Tahiya Alam, Alaa Alashi, S. Alavian, K. Alene, M. Alijanzadeh, Reza Alizadeh-Navaei, S. Aljunid, A. Alkerwi, François Alla, Peter Allebeck, M. Alouani, K. Altirkawi, N. Alvis-Guzmán, Azmeraw T. Amare, L. Aminde, W. Ammar, Y. Amoako, N. Anber, C. Andrei, S. Androudi, Megbaru Debalkie Animut, Mina Anjomshoa, Mustafa Geleto Ansha, C. Antonio, P. Anwari, J. Arabloo, Antonio Arauz, O. Aremu, F. Ariani, Bahroom Armoon, Johan Ärnlöv, Amit Arora, A. Artaman, K. Aryal, H. Asayesh, R. J. Asghar, Z. Ataro, Sachin R Atre, M. Ausloos, L. Ávila-Burgos, Euripide Avokpaho, A. Awasthi, B. P. Ayala Quintanilla, R. Ayer, P. Azzopardi, A. Babazadeh, Hamid Badali, A. Badawi, A. G. Bali, Katherine E Ballesteros, S. Ballew, Maciej Banach, J. Banoub, A. Banstola, A. Barać, Miguel A Barboza, S. Barker-Collo, T. Bärnighausen, L. Barrero, B. Baune, S. Bazargan-Hejazi, Neeraj Bedi, Ettore Beghi, Masoud Behzadifar, M. Behzadifar, Y. Béjot, A. Belachew, Yihalem Abebe Belay, Michelle L. Bell, A. Bello, I. Benseñor, Eduardo Bernabé, Robert S. Bernstein, M. Beuran, Tina Beyranvand, N. Bhala, S. Bhattarai, Soumyadeep Bhaumik, Z. Bhutta, B. Biadgo, A. Bijani, B. Bikbov, V. Bilano, Nigus Bililign, M. B. Bin Sayeed, D. Bisanzio, B. Blacker, F. Blyth, I. Bou-Orm, S. Boufous, R. Bourne, Oliver J. Brady, Michael Brainin, L. Brant, A. Brazinova, N. Breitborde, H. Brenner, P. Briant, Andrew M Briggs, A. Briko, Gabrielle Britton, T. Brugha, Rachelle Buchbinder, Reinhard Busse, Z. Butt, Lucero Cahuana-Hurtado, Jorge Cano, Rosario Cárdenas, J. Carrero, A. Carter, F. Carvalho, C. Castañeda-Orjuela, Jacqueline Castillo Rivas, Franz Castro, Ferrán Catalá-López, Kelly M. Cercy, Ester Cerin, Y. Chaiah, Alex R. Chang, Hsing-Yi Chang, Jung-Chen Chang, F. Charlson, Aparajita Chattopadhyay, Vijay Kumar Chattu, Pankaj Chaturvedi, P. Chiang, Ken Lee Chin, Abdulaal Chitheer, J. Choi, Rajiv Chowdhury, H. Christensen, D. Christopher, F. Cicuttini, Liliana G. Ciobanu, Massimo Cirillo, R. Claro, D. Collado-Mateo, Cyrus Cooper, J. Coresh, P. Cortesi, Monica Cortinovis, Megan Costa, Ewerton Cousin, M. Criqui, Elizabeth A. Cromwell, M. Cross, J. Crump, A. Dadi, L. Dandona, R. Dandona, P. Dargan, A. Daryani, R. Das Gupta, J. D. das Neves, T. Dasa, Gail Davey, A. Davis, D. Davițoiu, B. de Courten, Fernando Pio De la Hoz, Diego De Leo, Jan‐Walter De Neve, M. G. Degefa, L. Degenhardt, Selina Deiparine, R. Dellavalle, Gebre Teklemariam Demoz, Kebede Deribe, Nikolaos Dervenis, D. D. Des Jarlais, Getenet Dessie, Subhojit Dey, S. Dharmaratne, Mesfin Tadese Dinberu, M. Dirac, S. Djalalinia, L. Doan, K. Dokova, D. Doku, E. R. Dorsey, Kerrie E. Doyle, T. Driscoll, M. Dubey, E. Dubljanin, Eyasu Ejeta Duken, B. B. Duncan, A. Durães, H. Ebrahimi, S. Ebrahimpour, M. Echko, D. Edvardsson, Andem Effiong, Joshua R. Ehrlich, C. El Bcheraoui, M. El Sayed Zaki, Z. El-Khatib, H. Elkout, Iqbal Elyazar, A. Enayati, A. Endries, Benjamin Er, H. Erskine, B. Eshrati, S. Eskandarieh, Alireza Esteghamati, S. Esteghamati, H. Fakhim, Vahid Fallah Omrani, Mahbobeh Faramarzi, Mohammad Fareed, F. Farhadi, Talha A Farid, C. Farinha, Andrea Farioli, Andre Faro, M. Farvid, F. Farzadfar, Valery L. Feigin, Netsanet Fentahun, S. Fereshtehnejad, Eduarda Fernandes, João C Fernandes, A. Ferrari, Garumma Tolu Feyissa, I. Filip, Florian Fischer, C. Fitzmaurice, N. Foigt, Kyle Foreman, Jack T Fox, Tahvi D Frank, Takeshi Fukumoto, N. Fullman, Thomas Fürst, João M. Furtado, Neal D Futran, S. Gall, M. Ganji, F. Gankpé, A. García-Basteiro, William M Gardner, A. Gebre, A. Gebremedhin, Teklu Gebrehiwo Gebremichael, Tilayie Feto Gelano, J. Geleijnse, R. Gènova-Maleras, Y. C. D. Geramo, P. Gething, Kebede Embaye Gezae, K. Ghadiri, Khalil Ghasemi Falavarjani, Maryam Ghasemi-Kasman, M. Ghimire, Rakesh Ghosh, Aloke G Ghoshal, Simona Giampaoli, P. Gill, Tiffany K. Gill, I. Ginawi, G. Giussani, E. Gnedovskaya, Ellen M. Goldberg, Srinivas Goli, H. Gómez-Dantés, P. Gona, S. Gopalani, Taren M Gorman, A. Goulart, B. N. Goulart, A. Grada, Morgan E. Grams, Giuseppe Grosso, H. Gugnani, Yuming Guo, Prakash C Gupta, Rahul Gupta, Rajeev Gupta, Tanush Gupta, Bishal Gyawali, J. Haagsma, Vladimir Hachinski, N. Hafezi-Nejad, Hassan Haghparast Bidgoli, Tekleberhan B Hagos, G. B. Hailu, Arvin Haj-Mirzaian, A. Haj-Mirzaian, R. Hamadeh, S. Hamidi, A. Handal, Graeme J. Hankey, Yuantao Hao, H. Harb, S. Harikrishnan, J. Haro, M. Hasan, H. Hassankhani, H. Y. Hassen, Rasmus J. Havmoeller, Caitlin N Hawley, Roderick J Hay, Simon Iain Hay, A. Hedayatizadeh-Omran, B. Heibati, D. Hendrie, A. Henok, C. Herteliu, Sousan Heydarpour, D. Hibstu, H. T. Hoang, Hans W. Hoek, Howard J Hoffman, M. K. Hole, Enayatollah Homaie Rad, P. Hoogar, H. Hosgood, Seyed Mostafa Hosseini, M. Hosseinzadeh, M. Hostiuc, S. Hostiuc, Peter J. Hotez, D. Hoy, M. Hsairi, A. Htet, Guoqing Hu, John J Emmanuel Huang, Chantal K Huynh, K. Iburg, C. Ikeda, B. Ileanu, O S Ilesanmi, Usman Iqbal, S. Irvani, C. Irvine, Sheikh Mohammed Shariful Islam, F. Islami, K. Jacobsen, L. Jahangiry, N. Jahanmehr, Sudhir Kumar Jain, Mihajlo Jakovljevic, Mehdi Javanbakht, A. Jayatilleke, P. Jeemon, R. P. Jha, Vivekanand Jha, John S Ji, C. Johnson, J. Jonas, J. Jozwiak, Suresh Jungari, M. Jürisson, Zubair Kabir, R. Kadel, Amaha Kahsay, Rizwan Kalani, T. Kanchan, Manoochehr Karami, B. Karami Matin, André Karch, C. Karema, Narges Karimi, Seyed M. Karimi, A. Kasaeian, D. H. Kassa, G. Kassa, T. Kassa, N. Kassebaum, S. Katikireddi, Norito Kawakami, Ali Kazemi Karyani, Masoud Keighobadi, P. Keiyoro, L. Kemmer, Grant Rodgers Kemp, A. Kengne, Andre Keren, Yousef S. Khader, Behzad Khafaei, M. Khafaie, Alireza Khajavi, I. Khalil, E. Khan, M. Khan, Muhammad Ali Khan, Y. Khang, Mohammad Khazaei, A. Khoja, A. Khosravi, Mohammad Hossein Khosravi, A. Kiadaliri, Daniel N. Kiirithio, Cho-il Kim, Daniel H. Kim, Pauline Kim, Young-Eun Kim, Yun Jin Kim, R. Kimokoti, Y. Kinfu, A. Kisa, K. Kissimova-Skarbek, Mika Kivimäki, A. Knudsen, Jonathan M Kocarnik, S. Kochhar, Y. Kokubo, Tufa Kolola, Jacek A. Kopec, S. Kosen, G. Kotsakis, P. Koul, Ai Koyanagi, M. Kravchenko, K. Krishan, Kristopher J. Krohn, Barthelemy Kuate Defo, B. Kucuk Bicer, G. Kumar, Manasi Kumar, H. Kyu, Deepesh P. Lad, S. Lad, A. Lafranconi, R. Lalloo, T. Lallukka, Faris Lami, V. Lansingh, A. Latifi, Kathryn M. Lau, J. Lazarus, J. Leasher, J. R. Ledesma, P. H. Lee, J. Leigh, Janni Leung, Miriam Levi, Sonia Lewycka, Shanshan Li, Yichong Li, Yu Liao, Misgan Legesse Liben, Lee-Ling Lim, Stephen S. Lim, Shiwei Liu, R. Lodha, Katharine J Looker, A. D. Lopez +499 moresemanticscholar +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more source
