Results 81 to 90 of about 9,539,267 (257)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Global disease detection by the numbers : select accomplishments from GDD Centers, 2006-2016 [PDF]

10 \ue2\u20ac\u201c GDD Centers help countries build core capacities in support of the International Health Regulations and Global Health Security50+ \ue2\u20ac\u201c Countries received outbreak response, laboratory, and surveillance support from GDD ...

core  

Learning about Barriers to Care for People Living with HIV in Egypt

Journal of the International Association of Providers of AIDS Care, 2015
The purpose of this study was to identify obstacles health care workers face in providing care for people living with HIV and AIDS (PLWHA). Based on these findings, health authorities can design interventions to support health care workers in providing ...
Ihab Abdelrahman PhD, Anna Leena Lohiniva MA, Amr Kandeel PhD, Manal Benkirane MPH, Hossam Atta MD, Hanan Saleh MD, Nasr El Sayed MD, MPH, Maha Talaat PhD   +7 more
doaj   +1 more source

Prevalence of enteric infections among hospitalized patients in two referral hospitals in Ghana

BMC Research Notes, 2017
Background Diarrhea is an important cause of morbidity and mortality worldwide. In Africa and Ghana in particular, it is estimated to contribute directly to 19 and 25% of pediatric mortality among children under 5 years, respectively.
R. Akuffo, G. Armah, M. Clemens, K. C. Kronmann, A. H. Jones, P. Agbenohevi, K. Sagoe, N. Puplampu, N. Talla Nzussouo, W. Ampofo, K. Koram, C. Duplessis, E. Dueger   +12 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Antiviral Activity and Underlying Mechanism of Moslae herba Aqueous Extract for Treating SARS-CoV-2

Molecules
Despite the widespread use of COVID-19 vaccines, there is still a global need to find effective therapeutics to deal with the variants of SARS-CoV-2. Moslae herba (MH) is a herbal medicine credited with antiviral effects.
Yan Feng, Qiong Ge, Jian Gao, Zhuoying Wu, Yunyi Zhang, Haiyan Mao, Beibei Wu, Changping Xu   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Modeling disease vector occurrence when detection is imperfect: infestation of Amazonian palm trees by triatomine bugs at three spatial scales. [PDF]

, 2010
BACKGROUND: Failure to detect a disease agent or vector where it actually occurs constitutes a serious drawback in epidemiology. In the pervasive situation where no sampling technique is perfect, the explicit analytical treatment of detection failure ...
Mario J Grijalva, Gonçalo Ferraz, Aguilar, H Marcelo, Miles, Michael Alexander, H Marcelo Aguilar, Michael A Miles, Palomeque, Francisco S, Abad-Franch Fernando, Miles Michael A., Abad-Franch, Fernando, Miles, Michael A., Grijalva, Mario J., Campos, Ciro, Palomeque, Francisco S., Aguilar, Hugo Marcelo V., Ferraz Gonçalo, Palomeque Francisco S., Fernando Abad-Franch, Francisco S Palomeque, Aguilar H. Marcelo, Aguilar, Hugo Marcelo, Miles, Michael A, Ferraz, Gonçalo, Ferraz, Gon??alo, Campos Ciro, Grijalva, Mario J, Grijalva Mario J., Ciro Campos, Grijalva, Mario   +28 more
core   +2 more sources

Influence of Age and Body Weight on Supramammary Lymph Node Morphology and Weight in Holstein Dairy Cows

Veterinary Sciences
This study aimed to investigate the morphological characteristics and weight of supramammary lymph nodes (SMLNs) in Holstein dairy cows and to evaluate the effects of age and body weight (BW) on these parameters.
Ran Guan, Chaoyun Yang, Zhiqiang Hu, Songhua Hu   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source