Results 31 to 40 of about 2,172,156 (199)

PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression

Scientific Reports
The preprotein convertase, Bacillus subtilis protease/kexin type 9 serine protease (PCSK9), has garnered significant attention as a potential lipid lowering and therapeutic drug target for atherosclerosis (AS).
Yuan feng Cui, Xiao cui Chen, Tuoluonayi Mijiti, Abidan Abudurusuli, Li hui Deng, Xiang Ma, Bangdang Chen   +6 more
doaj   +1 more source

Estimation of the Incidence of Lyme Disease [PDF]

American Journal of Epidemiology, 1998
The incidence of Lyme disease in most endemic areas is unknown but will be an important factor in determining the cost-effectiveness of Lyme disease vaccines in those areas. The authors developed a deterministic model with nine components to estimate the frequency of Ixodes scapularis tick bites and the resulting incidence of Lyme disease in residents ...
G L, Campbell, C L, Fritz, D, Fish, J, Nowakowski, R B, Nadelman, G P, Wormser   +5 more
openaire   +2 more sources

U.S. cancer statistics : Highlights from 2019 incidence [PDF]

In 2019, a total of 1,752,735 new invasive cancer cases were reported in the United States: 863,830 among females and 888,905 among males. For all cancers combined, the incidence rate was 439 per 100,000 standard population overall.

core   +2 more sources

Identification of natural compound garcinone E as a novel autophagic flux inhibitor with anticancer effect in nasopharyngeal carcinoma cells

Pharmaceutical Biology, 2023
Context Current chemotherapeutic drugs cannot meet the treatment needs of patients with nasopharyngeal carcinoma (NPC), so urgent action is needed to discover novel chemotherapeutic agents.
Dan Wei, Luolin Wang, Shunmei Lei, Han Zhang, Caihua Dong, Yao Ke, Yuting Su, Xiaoying Chen, Lianping Xia, Xiaoyang Kong, Fuqiang Yin, Xia Liu   +11 more
doaj   +1 more source

Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

BMC Genomics, 2021
Background Cystic echinococcosis (CE) is a life-threatening zoonosis caused by the larval form of Echinococcus granulosus tapeworm. Our previous study showed that an approved drug pyronaridine (PND) is highly effective against CE, both in vitro and in an
Yingfang Yu, Jun Li, Weisi Wang, Tian Wang, Wenjing Qi, Xueting Zheng, Lei Duan, Jiaxu Chen, Shizhu Li, Xiumin Han, Wenbao Zhang, Liping Duan   +11 more
doaj   +1 more source

Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort. [PDF]

, 2014
OBJECTIVES: The role of outdoor air pollution in the incidence of chronic obstructive pulmonary disease (COPD) remains unclear. We investigated this question using a large, nationally representative cohort based on primary care records linked to hospital
Van Staa, Tjeerd; id_orcid, van Staa, TP, Anderson, HR, Carey, I M, Kent, AJ, Kent, A J, van Staa, T P, Atkinson, R W, Sub Pharmacoepidemiology, Atkinson, RW, Anderson, H R, Pharmacoepidemiology and Clinical Pharmacology, Carey, IM, Cook, DG, Cook, D G   +14 more
core   +1 more source

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host

Cellular and Molecular Life Sciences
Background Alveolar echinococcosis (AE) is a fatal zoonotic parasitic disease with biological characteristics similar to cancer. Although previous studies have reported immune dysfunction of Natural Killer (NK) cells due to other inhibitory receptors in ...
Ayinuer Aierken, Aili Aierken, Kalibixiati Aimulajiang, Abuduaini Abulizi, Zhongdian Yuan, Chang Liu, Dalong Zhu, Hanyue Zhao, Tuerganaili Aji   +8 more
doaj   +1 more source

Phenotype and function of MAIT cells in patients with alveolar echinococcosis

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a subpopulation of unconventional T cells widely involved in chronic liver diseases. However, the potential role and regulating factors of MAIT cells in alveolar echinococcosis (AE), a zoonotic parasitic ...
Jintian Li, Jintian Li, Hanyue Zhao, Hanyue Zhao, Guodong Lv, Kalibixiati Aimulajiang, Liang Li, Renyong Lin, Renyong Lin, Tuerganaili Aji, Tuerganaili Aji, Tuerganaili Aji   +11 more
doaj   +1 more source

Association between MIF gene promoter rs755622 and susceptibility to coronary artery disease and inflammatory cytokines in the Chinese Han population

Scientific Reports, 2021
Macrophage migration inhibitory factor (MIF) is an essential mediator of atherosclerotic plaque progression and instability leading to intracoronary thrombosis, therefore contributing to coronary artery disease (CAD).
Jun-Yi Luo, Bin-Bin Fang, Guo-Li Du, Fen Liu, Yan-Hong Li, Ting Tian, Xiao-Mei Li, Xiao-Ming Gao, Yi-Ning Yang   +8 more
doaj   +1 more source

The epidemiology of norovirus in England diagnostics, incidence and transmission [PDF]

Existing estimates of the incidence of infectious intestinal disease (IID) caused by norovirus in the community are based on electron microscopy or reverse transcription- polymerase chain reaction (RT-PCR).
Phillips, Gemma
core   +1 more source