Results 51 to 60 of about 1,958,979 (248)

Dilated cardiomyopathy signature metabolic marker screening: Machine learning and multi-omics analysis

Heliyon
Objects: Our aim was to identify changes in the metabolome in dilated cardiomyopathy (DCM) as well as to construct a metabolic diagnostic model for DCM. Methods: We utilized non-targeted metabolomics with a cross-sectional cohort of age- and sex-matched ...
Xiao-Lei Li, Aibibanmu Aizezi, Yan-Peng Li, Yan-Hong Li, Fen Liu, Qian Zhao, Xiang Ma, Dilare Adi, Yi-Tong Ma   +8 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

The impact of mesenchymal stromal cells on the proliferation and functional maturation of liver organoids

Biology Direct
Background The health burden of end-stage liver disease continues to grow, and orthotopic liver transplantation remains the only curative treatment. Three-dimensional (3D) culture systems support the in vitro culture of primary liver cells, allowing them
Sang Luo, Chunyang Mao, Fang Wu, Xiaofen Huang, Wenjun Wu, Ting Huang, Dan Liu   +6 more
doaj   +1 more source

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

Ekstrak Tanaman Binahong sebagai Pengendali Penyakit Hawar Pelepah Daun Padi

Jurnal Fitopatologi Indonesia, 2018
Binahong Extract for Controlling Sheath Blight Disease of Rice Paddy Sheath blight disease, caused by Rhizoctonia solani, is an important disease that can affect rice production. The disease is commonly controlled using synthetic fungicides.
Endah Yulia, Fitri Widiantini
doaj   +1 more source

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

Exploreing the potential mechanism of Aitongxiao formula inhibiting hepatocellular carcinoma in vitro and in vivo based on network Pharmacology

Scientific Reports
To explore the specific effects and potential mechanisms of Aitongxiao Formula (ATXF) in treating HCC. Network pharmacology was first used to predict the potential targets and pathways of ATXF against liver cancer.
Xiaoqing Zhao, Hu Zhou, Meng Xia, Qingqing Cheng, Rongzhi Wang, Junyu Tao, Jing Leng   +6 more
doaj   +1 more source

Assessment of Peacock Spot Disease (Fusicladium oleagineum) in Olive Orchards Through Agronomic Approaches and UAV-Based Multispectral Imaging

Horticulturae
Olive leaf spot (OLS), caused by Fusicladium oleagineum, is a significant disease affecting olive orchards, leading to reduced yields and compromising olive tree health.
Hajar Hamzaoui, Ilyass Maafa, Hasnae Choukri, Ahmed El Bakkali, Salma El Iraqui El Houssaini, Rachid Razouk, Aziz Aziz, Said Louahlia, Khaoula Habbadi   +8 more
doaj   +1 more source

Heritability and phenotypic correlation of resistance to Peanut bud necrosis virus (PBNV) and agronomic traits in peanut [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2004
Peanut bud necrosis virus (PBNV) is a potential threat to peanut production in Thailand. Therefore, the improvement of peanut lines, which are resistant to PBNV and maintain acceptable agronomic traits, is important.
Aran Patanothai, Sopone Wongkaew, Chutipong Akkasaeng, Nimitr Vorasoot, Sanun Jogloy, Thawan Kesmala   +5 more
doaj