Results 51 to 60 of about 7,687,257 (287)

Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

BMC Genomics, 2021
Background Cystic echinococcosis (CE) is a life-threatening zoonosis caused by the larval form of Echinococcus granulosus tapeworm. Our previous study showed that an approved drug pyronaridine (PND) is highly effective against CE, both in vitro and in an
Yingfang Yu, Jun Li, Weisi Wang, Tian Wang, Wenjing Qi, Xueting Zheng, Lei Duan, Jiaxu Chen, Shizhu Li, Xiumin Han, Wenbao Zhang, Liping Duan   +11 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Dilated cardiomyopathy signature metabolic marker screening: Machine learning and multi-omics analysis

Heliyon
Objects: Our aim was to identify changes in the metabolome in dilated cardiomyopathy (DCM) as well as to construct a metabolic diagnostic model for DCM. Methods: We utilized non-targeted metabolomics with a cross-sectional cohort of age- and sex-matched ...
Xiao-Lei Li, Aibibanmu Aizezi, Yan-Peng Li, Yan-Hong Li, Fen Liu, Qian Zhao, Xiang Ma, Dilare Adi, Yi-Tong Ma   +8 more
doaj   +1 more source

Association between MIF gene promoter rs755622 and susceptibility to coronary artery disease and inflammatory cytokines in the Chinese Han population

Scientific Reports, 2021
Macrophage migration inhibitory factor (MIF) is an essential mediator of atherosclerotic plaque progression and instability leading to intracoronary thrombosis, therefore contributing to coronary artery disease (CAD).
Jun-Yi Luo, Bin-Bin Fang, Guo-Li Du, Fen Liu, Yan-Hong Li, Ting Tian, Xiao-Mei Li, Xiao-Ming Gao, Yi-Ning Yang   +8 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

The impact of mesenchymal stromal cells on the proliferation and functional maturation of liver organoids

Biology Direct
Background The health burden of end-stage liver disease continues to grow, and orthotopic liver transplantation remains the only curative treatment. Three-dimensional (3D) culture systems support the in vitro culture of primary liver cells, allowing them
Sang Luo, Chunyang Mao, Fang Wu, Xiaofen Huang, Wenjun Wu, Ting Huang, Dan Liu   +6 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

To establish an indirect ELISA method for the detection of human brucellosis based on signal peptide-truncated recombinant Cu/Zn SOD and its preliminary clinical verification

Frontiers in Cellular and Infection Microbiology
BackgroundSerological diagnosis of brucellosis is hindered by cross-reactivity with lipopolysaccharide (LPS) antigens, resulting in insufficient specificity and sensitivity, which remains one of the major bottlenecks in current clinical testing for ...
Chao Wei, Chanjuan Zhang, Meiling Ren, Kaiting Zhang, Huanhuan Yang, Ruiyan Han, Zixuan Dong, Songsong Xie   +7 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis

Frontiers in Cellular and Infection Microbiology
Ghrelin widely exists in the central nervous system and peripheral organs, and has biological activities such as maintaining energy homeostasis, regulating lipid metabolism, cell proliferation, immune response, gastrointestinal physiological activities ...
Jiang Zhu, Jiang Zhu, Tanfang Zhou, Tanfang Zhou, Meng Menggen, Kalibixiati Aimulajiang, Hao Wen, Hao Wen   +7 more
doaj   +1 more source