Results 41 to 50 of about 1,958,979 (248)

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host

Cellular and Molecular Life Sciences
Background Alveolar echinococcosis (AE) is a fatal zoonotic parasitic disease with biological characteristics similar to cancer. Although previous studies have reported immune dysfunction of Natural Killer (NK) cells due to other inhibitory receptors in ...
Ayinuer Aierken, Aili Aierken, Kalibixiati Aimulajiang, Abuduaini Abulizi, Zhongdian Yuan, Chang Liu, Dalong Zhu, Hanyue Zhao, Tuerganaili Aji   +8 more
doaj   +1 more source

Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

BMC Genomics, 2021
Background Cystic echinococcosis (CE) is a life-threatening zoonosis caused by the larval form of Echinococcus granulosus tapeworm. Our previous study showed that an approved drug pyronaridine (PND) is highly effective against CE, both in vitro and in an
Yingfang Yu, Jun Li, Weisi Wang, Tian Wang, Wenjing Qi, Xueting Zheng, Lei Duan, Jiaxu Chen, Shizhu Li, Xiumin Han, Wenbao Zhang, Liping Duan   +11 more
doaj   +1 more source

Identification of natural compound garcinone E as a novel autophagic flux inhibitor with anticancer effect in nasopharyngeal carcinoma cells

Pharmaceutical Biology, 2023
Context Current chemotherapeutic drugs cannot meet the treatment needs of patients with nasopharyngeal carcinoma (NPC), so urgent action is needed to discover novel chemotherapeutic agents.
Dan Wei, Luolin Wang, Shunmei Lei, Han Zhang, Caihua Dong, Yao Ke, Yuting Su, Xiaoying Chen, Lianping Xia, Xiaoyang Kong, Fuqiang Yin, Xia Liu   +11 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

The association between Clonorchis sinensis seropositivity and hepatocellular carcinoma in an endemic area: a study in Guangxi, China

BMC Infectious Diseases
Background Chronic infection with Clonorchis sinensis (C.sinensis) has been associated swith the development of intrahepatic cholangiocarcinoma (ICC); however, the relationship between C.sinensis and hepatocellular carcinoma (HCC) remains uncertain ...
Qing-Li Yang, Xi-Wei Lu, Zhong-Liao Fang, Yu-Qiu Gao, Yi-Ning He, Yan Huang, Yue Dai, Ming-Yong Liang, Carlos H. F. Chan, Zhi-Hua Jiang   +9 more
doaj   +1 more source

Phenotype and function of MAIT cells in patients with alveolar echinococcosis

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a subpopulation of unconventional T cells widely involved in chronic liver diseases. However, the potential role and regulating factors of MAIT cells in alveolar echinococcosis (AE), a zoonotic parasitic ...
Jintian Li, Jintian Li, Hanyue Zhao, Hanyue Zhao, Guodong Lv, Kalibixiati Aimulajiang, Liang Li, Renyong Lin, Renyong Lin, Tuerganaili Aji, Tuerganaili Aji, Tuerganaili Aji   +11 more
doaj   +1 more source

Association between MIF gene promoter rs755622 and susceptibility to coronary artery disease and inflammatory cytokines in the Chinese Han population

Scientific Reports, 2021
Macrophage migration inhibitory factor (MIF) is an essential mediator of atherosclerotic plaque progression and instability leading to intracoronary thrombosis, therefore contributing to coronary artery disease (CAD).
Jun-Yi Luo, Bin-Bin Fang, Guo-Li Du, Fen Liu, Yan-Hong Li, Ting Tian, Xiao-Mei Li, Xiao-Ming Gao, Yi-Ning Yang   +8 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Highly cited original research in microneedle science from 2015 to 2025 a bibliometric and altmetric analysis

Discover Nano
This study comprehensively analyzes the top 100 highly cited publications in microneedle (MN) research to reveal convergences and divergences in academic and public interest, assess the current research landscape and its impact, and offer data-driven ...
Xuanrui Chen, Qian Zhang, Changbin Zhao, Guangbin Wang, Hailing Ren, Mingjing Yang, Shihui Liu, Tao Liu, Bin Guo   +8 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source