Results 41 to 50 of about 1,894,026 (247)

Dilated cardiomyopathy signature metabolic marker screening: Machine learning and multi-omics analysis

Heliyon
Objects: Our aim was to identify changes in the metabolome in dilated cardiomyopathy (DCM) as well as to construct a metabolic diagnostic model for DCM. Methods: We utilized non-targeted metabolomics with a cross-sectional cohort of age- and sex-matched ...
Xiao-Lei Li, Aibibanmu Aizezi, Yan-Peng Li, Yan-Hong Li, Fen Liu, Qian Zhao, Xiang Ma, Dilare Adi, Yi-Tong Ma   +8 more
doaj   +1 more source

Epidemiological features of COVID-19 in Iran

Journal of Research in Medical Sciences, 2022
Background: The first confirmed case of COVID-19 in Iran was reported in February 2019. The current study aimed to investigate the epidemiological aspects of COVID-19 disease in Isfahan province and evaluate the chances of infection and death in the ...
Negah Tavakolifard, Mina Moeini, Asefeh Haddadpoor, Zahra Amini, Kamal Heidari, Mostafa Rezaie   +5 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

The Influence of Soil Nutrients Availability on Banana Bunchy Top Disease Incidence in Banyumas Regency, Central Java Province, Indonesia

Caraka Tani: Journal of Sustainable Agriculture, 2023
The banana bunchy top is one of the important diseases on bananas, presumably coupled with the influence of soil properties, despite no fixed information regarding their relationship.
Ruly Eko Kusuma Kurniawan, Ruth Feti Rahayuniati, Nurtiati Nurtiati   +2 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis

Frontiers in Cellular and Infection Microbiology
Ghrelin widely exists in the central nervous system and peripheral organs, and has biological activities such as maintaining energy homeostasis, regulating lipid metabolism, cell proliferation, immune response, gastrointestinal physiological activities ...
Jiang Zhu, Jiang Zhu, Tanfang Zhou, Tanfang Zhou, Meng Menggen, Kalibixiati Aimulajiang, Hao Wen, Hao Wen   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis

Frontiers in Nutrition
BackgroundNon-alcoholic fatty liver disease (NAFLD) has become a public health issue worldwide. Dietary polyphenols are naturally occurring plant active ingredients and are widely employed in the treatment of NAFLD.
Xiao-cui Wang, Xiao-cui Wang, Li Song, Xin-han Wang, Xin-han Wang   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Exploreing the potential mechanism of Aitongxiao formula inhibiting hepatocellular carcinoma in vitro and in vivo based on network Pharmacology

Scientific Reports
To explore the specific effects and potential mechanisms of Aitongxiao Formula (ATXF) in treating HCC. Network pharmacology was first used to predict the potential targets and pathways of ATXF against liver cancer.
Xiaoqing Zhao, Hu Zhou, Meng Xia, Qingqing Cheng, Rongzhi Wang, Junyu Tao, Jing Leng   +6 more
doaj   +1 more source