Results 101 to 110 of about 1,230,509 (271)

Quantifying the mortality and morbidity impact of medicaid work requirements: a modeling studyResearch in context

open access: yesThe Lancet Regional Health. Americas
Summary: Background: Federal Medicaid work requirements, recently enacted under national legislation, are expected to cause substantial disenrollment among low-income adults.
Abhishek Pandey   +4 more
doaj   +1 more source

Mathematical Modeling for Inherited Diseases

open access: yesComputational and Mathematical Methods in Medicine, 2017
We introduced a new nonassociative algebra, namely, left almost algebra, and discussed some of its genetic properties. We discussed the relation of this algebra with flexible algebra, Jordan algebra, and generalized Jordan algebra.
Saima Anis, Madad Khan, Saqib Khan
openaire   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse Models of Alzheimers Disease

open access: yes, 2018
To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions.
Anderson, RJ   +9 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?

open access: yesCellular & Molecular Biology Letters
Immune-resistant pancreatic islets hold great promise for advancing diabetes cell therapy. Two key approaches, hypoimmunogenic pluripotent stem cells (PSCs) and hypoimmunogenic cadaveric islets, aim to overcome immune rejection in islet transplantation ...
Karim E. Shalaby, Essam M. Abdelalim
doaj   +1 more source

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