Results 211 to 220 of about 1,236,451 (244)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Promoting mitochondrial dynamics by inhibiting the PINK1–PRKN pathway to relieve diabetic nephropathy

Disease Models & Mechanisms
Jun-yi Zhu, Joyce van de Leemput, Zhe Han   +2 more
doaj   +1 more source

Reproducibility of PD patient-specific midbrain organoid data for <i>in vitro</i> disease modeling. [PDF]

iScience
Zuccoli E, Al Sawaf H, Tuzza M, Nickels SL, Zagare A, Schwamborn JC.   +5 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Ex Vivo Organ Perfusion Systems for Disease Modeling and Therapeutic Applications in Small Animal Models. [PDF]

J Tissue Eng Regen Med
Yeganeh M, Zito A, Sadat M, Pierro A, Rogers IM.   +4 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Engineering Three-Dimensional Cellular Organization by Regulating Bound Water-Mediated Cell-Substrate Interactions for Disease Modeling. [PDF]

ACS Omega
Kawahara M, Miyazaki K, Anada T, Kobayashi S, Tanaka M.   +4 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Assessing Public Health Capacity for Infectious Disease Modeling: A Qualitative Study of State and Local Agencies. [PDF]

Int J Environ Res Public Health
Crouch SJ, Allen KS, Thornton D, Hartsell J, Weybright EH, Szymczak JE, Shoaf KI.   +6 more
europepmc   +1 more source

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening. [PDF]

Biomaterials
Nasiri R, Madadelahi M, Nikmaneshi MR, Gokce B, Bijarchi MA, Shah S, Tirpáková Z, Van Gastel D, Taebnia N, de Barros NR, Zhu Y, Morcimen ZG, Gulicli B, Habibey R, Sendemir A, Jain S, Enrico A, Lauschke VM, Dokmeci MR, Pratx G, Khademhosseini A, Herland A.   +21 more
europepmc   +1 more source