Results 211 to 220 of about 565,742 (268)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A quantum mechanics-based framework for infectious disease modeling. [PDF]

Sci Rep
He W, Bin S, Sun G.
europepmc   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine. [PDF]

Adv Sci (Weinh)
Huang R, Gao F, Yu L, Chen H, Zhu R.
europepmc   +1 more source

Advancing Esophageal Disease Modeling: Microfluidic Platforms for Adult Tissue-Resident Stem Cell Culture and Differentiation. [PDF]

Gastro Hep Adv
Hosseini-Farahabadi S, Abuhussein O, Stewart C, Gao G, Haglund T, Schaeffer D, Donnellan F, McKeon F, Xian W, Kelleher D, Duggan S.   +10 more
europepmc   +1 more source

A Flurry of Infectious Disease Modeling Tools During the COVID-19 Pandemic, Considerations for Future Selection. [PDF]

Pathogens
Corbin J, Cerles A, Tebon P, Haverkate M, Campbell S, Hurst J, Woodul R, Hunzeker J, Schwartz-Watjen K, Owens A, Wu A.   +10 more
europepmc   +1 more source

Identification of Potential Therapeutic Agents for Type I Interferonopathy Using iPSC-Based Disease Modeling. [PDF]

J Clin Immunol
Natsumoto B, Shoda H, Tsuji M, Otsu M, Taniguchi H, Yamamoto K, Fujio K.   +6 more
europepmc   +1 more source

Reproducibility of PD patient-specific midbrain organoid data for <i>in vitro</i> disease modeling. [PDF]

iScience
Zuccoli E, Al Sawaf H, Tuzza M, Nickels SL, Zagare A, Schwamborn JC.   +5 more
europepmc   +1 more source

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Disease model: Parkinson's disease

Trends in Molecular Medicine, 2003
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. The pathology of PD is typified by the presence of cytoplasmic inclusions (Lewy bodies) containing alpha-synuclein and ubiquitin.
Shun, Shimohama, Hideyuki, Sawada, Yoshihisa, Kitamura, Takashi, Taniguchi   +3 more
openaire   +2 more sources

Models of Disease

2018
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez, Elena, López-Ruiz, Cristina, Antich, Carlos, Chocarro-Wrona, Juan Antonio, Marchal   +4 more
openaire   +2 more sources

Models of Parkinson's disease

Movement Disorders, 2003
AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
openaire   +2 more sources