Results 211 to 220 of about 567,069 (269)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine. [PDF]

Adv Sci (Weinh)
Huang R, Gao F, Yu L, Chen H, Zhu R.
europepmc   +1 more source

Advancing Esophageal Disease Modeling: Microfluidic Platforms for Adult Tissue-Resident Stem Cell Culture and Differentiation. [PDF]

Gastro Hep Adv
Hosseini-Farahabadi S, Abuhussein O, Stewart C, Gao G, Haglund T, Schaeffer D, Donnellan F, McKeon F, Xian W, Kelleher D, Duggan S.   +10 more
europepmc   +1 more source

A Comprehensive Adenoid Cystic Carcinoma-Derived Organoid Platform for Disease Modeling and Drug Screening Captures Interpatient Heterogeneity. [PDF]

Cells
Chai Y, Sui Y, Zhang X, Xie S, Kang Y, Feng Y, Shan X, Cai Z.   +7 more
europepmc   +1 more source

A Flurry of Infectious Disease Modeling Tools During the COVID-19 Pandemic, Considerations for Future Selection. [PDF]

Pathogens
Corbin J, Cerles A, Tebon P, Haverkate M, Campbell S, Hurst J, Woodul R, Hunzeker J, Schwartz-Watjen K, Owens A, Wu A.   +10 more
europepmc   +1 more source

Identification of Potential Therapeutic Agents for Type I Interferonopathy Using iPSC-Based Disease Modeling. [PDF]

J Clin Immunol
Natsumoto B, Shoda H, Tsuji M, Otsu M, Taniguchi H, Yamamoto K, Fujio K.   +6 more
europepmc   +1 more source

Reproducibility of PD patient-specific midbrain organoid data for <i>in vitro</i> disease modeling. [PDF]

iScience
Zuccoli E, Al Sawaf H, Tuzza M, Nickels SL, Zagare A, Schwamborn JC.   +5 more
europepmc   +1 more source

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Disease model: Parkinson's disease

Trends in Molecular Medicine, 2003
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. The pathology of PD is typified by the presence of cytoplasmic inclusions (Lewy bodies) containing alpha-synuclein and ubiquitin.
Shun, Shimohama, Hideyuki, Sawada, Yoshihisa, Kitamura, Takashi, Taniguchi   +3 more
openaire   +2 more sources

Models of Disease

2018
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez, Elena, López-Ruiz, Cristina, Antich, Carlos, Chocarro-Wrona, Juan Antonio, Marchal   +4 more
openaire   +2 more sources

Models of mitochondrial disease

2002
Publisher Summary This chapter discusses the molecular mechanisms of disease pathogenesis and describes cell and animal models of respiratory-chain disease. The models that have been developed can be used to address a number of different issues: to demonstrate whether the cause of a given respiratory-chain disease is because of a nuclear or a ...
Danae, Liolitsa, Michael G, Hanna
openaire   +2 more sources