Results 241 to 250 of about 1,230,509 (271)
Some of the next articles are maybe not open access.
2018
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD is still not fully understood. Several animal models have been established to study the mechanisms of PD.
Vuu My, Dung, Dang Thi Phuong, Thao
openaire +2 more sources
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD is still not fully understood. Several animal models have been established to study the mechanisms of PD.
Vuu My, Dung, Dang Thi Phuong, Thao
openaire +2 more sources
2018
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez +4 more
openaire +2 more sources
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez +4 more
openaire +2 more sources
Modeling gastrointestinal anthrax disease
Research in Microbiology, 2023Bacillus anthracis is a spore-forming microbe that persists in soil and causes anthrax disease. The most natural route of infection is ingestion by grazing animals. Gastrointestinal (GI) anthrax also occurs in their monogastric predators, including humans.
Oh, So Young +6 more
openaire +4 more sources
Movement Disorders, 2003
AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
openaire +2 more sources
AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
openaire +2 more sources
Trends in Molecular Medicine, 2001
Mutations in the APC gene are responsible for familial adenomatous polyposis (FAP) and for the majority of sporadic colorectal cancers. The establishment of genotype-phenotype correlations in FAP is often complicated by the great clinical variability observed among carriers of the same APC mutation even within the same kindred.
Fodde, Riccardo, Smits, Ron
openaire +1 more source
Mutations in the APC gene are responsible for familial adenomatous polyposis (FAP) and for the majority of sporadic colorectal cancers. The establishment of genotype-phenotype correlations in FAP is often complicated by the great clinical variability observed among carriers of the same APC mutation even within the same kindred.
Fodde, Riccardo, Smits, Ron
openaire +1 more source
Modelling plant disease epidemics
European Journal of Plant Pathology, 2003An epidemic is the progress of disease in time and space. Each epidemic has a structure whose temporal dynamics and spatial patterns are jointly determined by the pathosystem characteristics and environmental conditions. One of the important objectives in epidemiology is to understand such spatio-temporal dynamics via mathematical and statistical ...
A. van Maanen, X.-M. Xu
openaire +1 more source
Models of mitochondrial disease
2002Publisher Summary This chapter discusses the molecular mechanisms of disease pathogenesis and describes cell and animal models of respiratory-chain disease. The models that have been developed can be used to address a number of different issues: to demonstrate whether the cause of a given respiratory-chain disease is because of a nuclear or a ...
Danae, Liolitsa, Michael G, Hanna
openaire +2 more sources
Trends in Molecular Medicine, 2002
Fanconi anemia (FA) is a chromosomal instability syndrome characterized by the presence of pancytopenia, congenital malformations and cancer predisposition. Six genes associated with this disorder have been cloned, and mice with targeted disruptions of several of the FA genes have been generated. These mouse models display the characteristic FA feature
Jasmine C Y, Wong, Manuel, Buchwald
openaire +2 more sources
Fanconi anemia (FA) is a chromosomal instability syndrome characterized by the presence of pancytopenia, congenital malformations and cancer predisposition. Six genes associated with this disorder have been cloned, and mice with targeted disruptions of several of the FA genes have been generated. These mouse models display the characteristic FA feature
Jasmine C Y, Wong, Manuel, Buchwald
openaire +2 more sources
Repeat Expansion Disease Models
2018Repeat expansion disorders are a group of inherited neuromuscular diseases, which are caused by expansion mutations of repeat sequences in the disease-causing genes. Repeat expansion disorders include a class of diseases caused by repeat expansions in the coding region of the genes, producing mutant proteins with amino acid repeats, mostly the ...
Morio, Ueyama, Yoshitaka, Nagai
openaire +2 more sources
Disease model: photoreceptor degenerations
Trends in Molecular Medicine, 2001Retinal diseases can be caused by genetic or non-genetic factors, and typically involve specific cell layers within the retina. A large number of simple Mendelian gene defects are known to affect the photoreceptor cell layer. As photoreceptor cells cannot be maintained in vitro, the study of animal models is instrumental in understanding the disease ...
openaire +2 more sources