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Abstract Animal disease models provide valuable pre-clinical information to support progression of agents into human clinical studies. Examples of disease models by indication illustrate the diversity of the field.
Phil Ambery +2 more
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Phil Ambery +2 more
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Modeling Tick-Borne Disease: A Metapopulation Model
Bulletin of Mathematical Biology, 2006Recent increases in reported outbreaks of tick-borne diseases have led to increased interest in understanding and controlling epidemics involving these transmission vectors. Mathematical disease models typically assume constant population size and spatial homogeneity. For tick-borne diseases, these assumptions are not always valid.
Gaff, Holly D., Gross, Louis J.
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Disease modeling in genetic kidney diseases: mice
Cell and Tissue Research, 2017The mouse still represents arguably the most important mammal organism in research for modeling human genetic kidney diseases in vivo. Compared with many other mammal species, the breeding and maintenance of mice in the laboratory is relatively simple and cheap and reproduction cycles are short.
Andreas F, Hofmeister +3 more
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Disease modeling in genetic kidney diseases: zebrafish
Cell and Tissue Research, 2017Growing numbers of translational genomics studies are based on the highly efficient and versatile zebrafish (Danio rerio) vertebrate model. The increasing types of zebrafish models have improved our understanding of inherited kidney diseases, since they not only display pathophysiological changes but also give us the opportunity to develop and test ...
Heiko, Schenk +3 more
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Disease model: LAMP-2 enlightens Danon disease
Trends in Molecular Medicine, 2001Danon disease ('lysosomal glycogen storage disease with normal acid maltase') is characterized by a cardiomyopathy, myopathy and variable mental retardation. Mutations in the coding sequence of the lysosomal-associated membrane protein 2 (LAMP-2) were shown to cause a LAMP-2 deficiency in patients with Danon disease.
P, Saftig +3 more
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Disease model: pulmonary tuberculosis
Trends in Molecular Medicine, 2001In spite of a massive effort to apply the tools currently available for tuberculosis (TB) control, both in this country and abroad, it is clear that complicating factors [for example, HIV co-infection, drug resistance, lack of patient compliance with chemotherapy, variable efficacy of Bacille Calmette-Guerin (BCG) vaccine] will prevent disease control ...
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Parkinson's disease: animal models
2007Publisher Summary Animal models are an essential tool to study human diseases, not only to enable a thorough investigation into the mechanisms involved in the pathogenesis of a disease but also to help in the development of therapeutic strategies. This chapter describes genetic as well as pharmacological manipulations used to develop animal models ...
Ranjita, Betarbet, J Timothy, Greenamyre
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Disease models of autoimmunity
Trends in Immunology, 2005The dream of producing medically relevant scientific observations, which are then translated successfully into therapeutic modalities, is the driving force behind much laboratory research. Such noble aspirations have, however, been soured by an underlying stand-off between basic researchers and clinicians.
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Trends in Molecular Medicine, 2001
Very little is known about the molecular mechanisms of human aging. This, at least in part, derives from a paucity of appropriate animal models of aging. Until recently, the senescence-accelerated mouse was the only mammalian model of aging. However, novel mouse models that exhibit multiple aging phenotypes have been developed in the past few years by ...
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Very little is known about the molecular mechanisms of human aging. This, at least in part, derives from a paucity of appropriate animal models of aging. Until recently, the senescence-accelerated mouse was the only mammalian model of aging. However, novel mouse models that exhibit multiple aging phenotypes have been developed in the past few years by ...
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Neuromuscular Disease Models and Analysis
2009Neuromuscular diseases can affect the survival of peripheral neurons, their axons extending to peripheral targets, their synaptic connections onto those targets, or the targets themselves. Examples include motor neuron diseases such as amyotrophic lateral sclerosis, peripheral neuropathies, such as Charcot-Marie-Tooth diseases, myasthenias, and ...
Burgess, Robert W +2 more
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