Results 171 to 180 of about 13,239,682 (316)

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Nature, 2006
C. Day, D. Kaufmann, P. Kiepiela, Julia A. Brown, Eshia S. Moodley, S. Reddy, Elizabeth W. Mackey, Joseph D. Miller, A. Leslie, Chantal DePierres, Z. Mncube, Jaikumar Duraiswamy, Baogong Zhu, Q. Eichbaum, M. Altfeld, E. Wherry, H. Coovadia, P. Goulder, P. Goulder, P. Goulder, P. Klenerman, R. Ahmed, G. Freeman, B. D. Walker, B. D. Walker, B. D. Walker   +25 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simulation of long-term lecanemab treatment effect on Alzheimer's disease progression. [PDF]

Alzheimers Dement (N Y)
Williams T, Jang SR, Lanctôt KL, Kang A, Bloudek L, Wang G.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comparison of Disease Progression Between Amelanotic Melanoma and Melanotic Melanoma. [PDF]

Pigment Cell Melanoma Res
Aviv B, Noa BH, Lotan L, Sharon B.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Respiratory oscillometry identifies disease progression in interstitial lung disease. [PDF]

BMJ Open Respir Res
Dube R, Duran OA, Azuelos I, Cormier M, Dandurand RJ, Assayag D.   +5 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Choroid plexus remodeling linked to impaired CSF-mediated clearance and Alzheimer's disease progression. [PDF]

Alzheimers Dement
Yin H, Deng Y, Lu Z, Jiang Y, Zuo C, Li J, Guo L, Ying B, Battaglia G, Tian X, Gong Q, Alzheimer's Disease Neuroimaging Initiative (ADNI).   +11 more
europepmc   +1 more source