Results 171 to 180 of about 7,373,821 (305)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression. [PDF]

Alzheimers Dement
Lan G, Liao W, Jiang M, Zhu J, Ran W, Gonzalez-Ortiz F, Fan X, Yang H, Shi D, Zhang L, Li A, Cai Y, Sun P, He Z, Zhou X, Yang J, Zhu Y, Li M, Huang W, Liu B, Wang Y, Ma X, Ma R, Zhang Y, Huang C, Liu Z, Wang Q, Zhou L, Xie F, Han Y, Liang Z, Chen X, Dong M, Cheng G, Wang L, Luo B, Wang YJ, Chen X, Alzheimer's Disease Neuroimaging Initiative, Xin J, Peng G, Guo T.   +41 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

DNA Sensing Pathways in Innate Immunity: Implications for Alzheimer's Disease Progression and Therapy. [PDF]

Mol Neurobiol
Shi C, Liu Y, Zhu Y.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Effects of transmembrane protein 106B genetic variations on disease progression in Parkinson's disease. [PDF]

Front Aging Neurosci
Zhao W, Liang X, Hu B, Yu W, Wu J, Sun Y, Wang J, Fan Y.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Decomposing heterogeneity in disease progression speeds and pathways. [PDF]

NPJ Digit Med
Yada Y, Naoki H.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Association of sTREM2 and YKL-40 With Alzheimer's Disease Progression: A Systematic Review. [PDF]

Cureus
Babiker Mohamed RO, Elamin AM, Ali Ahmed SS, Mahmuod SB, Mohamed Hamid HA, Ahmed RAA, Aboaly MM.   +6 more
europepmc   +1 more source