Results 221 to 230 of about 12,599,414 (356)

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Nature, 2006
C. Day, D. Kaufmann, P. Kiepiela, Julia A. Brown, Eshia S. Moodley, S. Reddy, Elizabeth W. Mackey, Joseph D. Miller, A. Leslie, Chantal DePierres, Z. Mncube, Jaikumar Duraiswamy, Baogong Zhu, Q. Eichbaum, M. Altfeld, E. Wherry, H. Coovadia, P. Goulder, P. Goulder, P. Goulder, P. Klenerman, R. Ahmed, G. Freeman, B. Walker, B. Walker, B. Walker   +25 more
semanticscholar   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Clock genes in pancreatic disease progression: from circadian regulation to dysfunction. [PDF]

Ann Med
Zheng T, Wang K, Shi Q, Zhang L, Yan Q, Jiang W, Chen C, Zhao K, Feng J, Wang W.   +9 more
europepmc   +1 more source

Understanding the nature of renal disease progression

, 1997
Giuseppe Remuzzi, Piero Ruggenenti, Ariela Benigni   +2 more
openalex   +1 more source

A Longitudinal Study of Neutralizing Antibodies and Disease Progression in HIV‐1–Infected Subjects [PDF]

, 1999
D. Cecilia, Cynthia A. Kleeberger, Álvaro Muñoz, Janis V. Giorgi, Susan Zolla‐Pazner   +4 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Regression and Non-Progression of Coronary Artery Disease with Exercise [PDF]

, 1996
Gerhard Schüler, Rainer Hambrecht
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Unlocking amyotrophic lateral sclerosis: the role of adiponectin in inflammation and disease progression. [PDF]

Front Neurol
Tian M, Xin C, Huo J, Liu Q, Dong H, Bai L, Wang Y, Li R, Liu Y.   +8 more
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source