Results 261 to 270 of about 12,789,497 (387)
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Nature Network Boston, 2019 O. Preische, Stephanie A. Schultz, Anja Apel, J. Kuhle, S. Kaeser, Christian Barro, S. Gräber, Elke Kuder-Buletta, C. Lafougère, C. Laske, J. Vöglein, J. Levin, C. Masters, R. Martins, P. Schofield, M. Rossor, N. Graff-Radford, S. Salloway, B. Ghetti, J. Ringman, James M. Noble, J. Chhatwal, A. Goate, T. Benzinger, J. Morris, R. Bateman, Guoqiao Wang, A. Fagan, E. McDade, B. Gordon, M. Jucker, Ricardo Fatima Randall Tammie Sarah Courtney Susan William Allegri Amtashar Bateman Benzinger Berman Bodge Br, R. Allegri, Fatima S. Amtashar, R. Bateman, T. Benzinger, S. Berman, Courtney A. Bodge, S. Brandon, W. Brooks, Jill Buck, V. Buckles, Sochenda Chea, J. Chhatwal, Patricio Chrem, H. Chui, J. Cinco, J. Clifford, Carlos Cruchaga, Mirelle D’Mello, Tamara Donahue, J. Douglas, Noelia Edigo, Nilufer Erekin-Taner, A. Fagan, M. Farlow, Angela M. Farrar, H. Feldman, Gigi Flynn, Nick C Fox, E. Franklin, H. Fujii, Cortaiga Gant, S. Gardener, B. Ghetti, A. Goate, J. Goldman, B. Gordon, N. Graff-Radford, Julia D. Gray, J. Gurney, Jason J Hassenstab, Mie Hirohara, D. Holtzman, R. Hornbeck, Siri Houeland DiBari, T. Ikeuchi, Snezana Ikonomovic, Gina Jerome, M. Jucker, C. Karch, K. Kasuga, T. Kawarabayashi, W. Klunk, R. Koeppe, Elke Kuder-Buletta, C. Laske, Jae-Hong Lee, D. Marcus, R. Martins, N. Mason, C. Masters, Denise Maue-Dreyfus, E. McDade, Lucy Montoya, H. Mori, J. Morris, Akem Nagamatsu, Katie Neimeyer, James M. Noble, J. Norton, R. Perrin, M. Raichle, J. Ringman, J. Roh, S. Salloway, P. Schofield, H. Shimada, Tomoyo Shiroto, M. Shoji, Wendy C. Sigurdson, H. Sohrabi, Paige Sparks, Kazushi Suzuki, Laura M Swisher, K. Taddei, Jen C. Wang, Peter Wang, M. Weiner, Mary A. Wolfsberger, C. Xiong, Xiong Xu +121 moresemanticscholar +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more source