Results 41 to 50 of about 12,789,497 (387)

Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme

BMC Cancer, 2020
Background The standard first- and second- line chemotherapy backbone regimens for metastatic colorectal cancer (mCRC) are 5-fluorouracil (5-FU)/capecitabine-based with addition of irinotecan or oxaliplatin.
Timothy Iveson, Angela M. Carter, Kai-Keen Shiu, Clare Spooner, Daniel Stevens, Saifee Mullamitha   +5 more
doaj   +1 more source

Unblinding at disease progression in double-blinded randomized controlled cancer drug clinical trials: A controversy requires more attention

Frontiers in Medicine, 2022
Unblinding at disease progression in double-blinded randomized controlled cancer drug clinical trials is ethical to the patient by ensuring optimal subsequent treatment, but the effect of study treatment on overall survival may be confounded.
Wu Dawei, Miao Shuangman, Huang Huiyao, Cui Dandan, Tang Yu, Li Ning   +5 more
doaj   +1 more source

Statistical Disease Progression Modeling in Alzheimer Disease

Frontiers in Big Data, 2020
Background: The characterizing symptom of Alzheimer disease (AD) is cognitive deterioration. While much recent work has focused on defining AD as a biological construct, most patients are still diagnosed, staged, and treated based on their cognitive ...
L. L. Rakêt
semanticscholar   +1 more source

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
A Hainard, B Beutler, B Courtioux, B Namangala, CA Hunter, CA Hunter, CF Calvo, EN Benveniste, F Checchi, F Esamai, G Binz, H Reiber, H Reiber, H Reiber, Hansotto Reiber, HY Hassan, J Kabore, J Rodgers, Jeremy M. Sternberg, JM Sternberg, JM Sternberg, JM Sternberg, Joseph Mathu Ndung'u, KW Moore, L Maclean, L MacLean, L MacLean, L MacLean, LJ Morrison, LM MacLean, Lorna MacLean, M Sjogren, MC Okomo-Assoumou, P Cattand, PD Eckersall, Peter G. E. Kennedy, PG Kennedy, PGE Kennedy, PGE Kennedy, TN Baral, V Jamonneau, V Lejon, V Lejon, V Lejon, W Masocha   +44 more
core   +4 more sources

Metabolome in progression to Alzheimer's disease [PDF]

Translational Psychiatry, 2011
Mild cognitive impairment (MCI) is considered as a transition phase between normal aging and Alzheimer's disease (AD). MCI confers an increased risk of developing AD, although the state is heterogeneous with several possible outcomes, including even improvement back to normal cognition.
Hyötyläinen, Tuulia, Herukka, S.-K., Sysi-Aho, Marko, Mattila, I., Seppänen-Laakso, Tuulikki, Julkunen, V., Gopalacharyulu, P.V., Hallikainen, M., Koikkalainen, Juha, Kivipelto, M., Helisalmi, S., Lötjönen, Jyrki, Soininen, H., Orešič, Matej   +14 more
openaire   +5 more sources

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis. [PDF]

, 2017
BackgroundAlthough the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated.
Ambale-Venkatesh, Bharath, Bahrami, Hossein, Bakhshi, Hooman, Bluemke, David A, Budoff, Matthew, Lima, João AC, Ostovaneh, Mohammad R, Wong, Nathan D, Wu, Colin O, Yang, Xiaoying   +9 more
core   +2 more sources

Multiple exposures, reinfection and risk of progression to active tuberculosis [PDF]

Royal Society Open Science, 2019
A recent study reported on a tuberculosis (TB) outbreak in a largely Inuit village. Among newly infected individuals, exposure to additional active cases was associated with an increasing probability of developing active disease within a year.
Sarah F. Ackley, Robyn S. Lee, Lee Worden, Erin Zwick, Travis C. Porco, Marcel A. Behr, Caitlin S. Pepperell   +6 more
doaj   +1 more source

Clinical characteristics and analysis of risk factors for disease progression of patients with SARS-CoV-2 Omicron variant infection: A retrospective study of 25207 cases in a Fangcang hospital

Frontiers in Cellular and Infection Microbiology, 2022
ObjectivesTo summarize the clinical characteristics of patients infected by SARS-CoV-2 omicron variant and explore the risk factors affecting the progression in a Fangcang hospital, Shanghai, China.MethodsA total of 25,207 patients were retrospectively ...
Pei Ying-hao, Gu Yuan-yuan, Zhang Hai-dong, Chen Qiu-hua, Gu Xue-ran, Zhou Hai-qi, Jiang Hua   +6 more
doaj   +1 more source

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]

, 2015
background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S., Bottcher, R., Dulla, K., Henderson, D. J. P., Hoffmann, R., Houslay, M. D., Jenster, G., Lehman, M. L., Merkle, D., Tevz, G., van Leenders, G. J. L. H., van Strijp, D., Waanders, L. F.   +12 more
core   +1 more source

The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients

Frontiers in Immunology, 2023
IntroductionThe pathophysiology of the Corona Virus Disease 2019 (COVID-19) is incompletely known. A robust inflammatory response caused by viral replication is a main cause of the acute lung and multiorgan injury observed in critical patients ...
Valentina Vultaggio-Poma, Juana Maria Sanz, Andrea Amico, Alessandra Violi, Sara Ghisellini, Stefano Pizzicotti, Angelina Passaro, Alberto Papi, Marco Libanore, Francesco Di Virgilio, Anna Lisa Giuliani   +10 more
doaj   +1 more source