Results 41 to 50 of about 12,637,526 (357)

Evolution of lung pathology in lymphangioleiomyomatosis: associations with disease course and treatment response

The Journal of Pathology: Clinical Research, 2020
Lymphangioleiomyomatosis (LAM) is a rare multisystem disease with a variable clinical course. The lungs are infiltrated by nodules of LAM cells, stromal cells and inflammatory cells, causing lung cysts and respiratory failure. We used immunohistochemical
Suzanne Miller, Iain D Stewart, Debbie Clements, Irshad Soomro, Roya Babaei‐Jadidi, Simon R Johnson   +5 more
doaj   +1 more source

Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study [PDF]

, 2020
BACKGROUND: Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability.
Bahr, Lina Samira, Bellmann-Strobl, Judith, Bock, Markus, Franz, Liane, Kessler, Christian S., Liebscher, Daniela, Michalsen, Andreas, Mähler, Anja, Paul, Friedemann, Piper, Sophie K., Prüß, Alexandra, Schumann, Dania, Steckhan, Nico   +12 more
core   +2 more sources

Multi-stage Biomarker Models for Progression Estimation in Alzheimer’s Disease [PDF]

, 2015
The estimation of disease progression in Alzheimer’s disease (AD) based on a vector of quantitative biomarkers is of high interest to clinicians, patients, and biomedical researchers alike.
Alejandro F. Frangi, Alexander Schmidt-Richberg, Christian Ledig, Daniel Rueckert, Helena Molina-Abril, null null, Ricardo Guerrero   +6 more
core   +1 more source

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Cell Research, 2019
Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure.
Xinyi Wang, Guangqiang Sun, T. Feng, Jing Zhang, Xun Huang, Tao Wang, Zuoquan Xie, Xingkun Chu, Jun Yang, Huan Wang, Shuaishuai Chang, Yanxue Gong, Lingfei Ruan, Guanqun Zhang, Siyuan Yan, Wen-Ping Lian, Chen Du, Dabing Yang, Qingli Zhang, Feifei Lin, Jia Liu, Haiyan Zhang, Changrong Ge, S. Xiao, Jian Ding, M. Geng   +25 more
semanticscholar   +1 more source

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis. [PDF]

, 2017
BackgroundAlthough the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated.
Ambale-Venkatesh, Bharath, Bahrami, Hossein, Bakhshi, Hooman, Bluemke, David A, Budoff, Matthew, Lima, João AC, Ostovaneh, Mohammad R, Wong, Nathan D, Wu, Colin O, Yang, Xiaoying   +9 more
core   +2 more sources

Machine learning for comprehensive forecasting of Alzheimer’s Disease progression [PDF]

Scientific Reports, 2018
Most approaches to machine learning from electronic health data can only predict a single endpoint. The ability to simultaneously simulate dozens of patient characteristics is a crucial step towards personalized medicine for Alzheimer’s Disease. Here, we
Charles K. Fisher, Aaron M. Smith, J. Walsh, Adam J. Chris Clifford R. David David Derek Donald Fred Simon Edgar Jack Holtzman Russell Hill Grosset Woo, A. Simon, Chris Edgar, C. Jack, D. Holtzman, D. Russell, D. Hill, D. Grosset, Fred Wood, H. Vanderstichele, J. Morris, K. Blennow, K. Marek, L. Shaw, M. Albert, M. Weiner, Nick Fox, P. Aisen, P. Cole, Ronald Petersen, T. Sherer, W. Kubick   +24 more
semanticscholar   +1 more source

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]

, 2015
background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S., Bottcher, R., Dulla, K., Henderson, D. J. P., Hoffmann, R., Houslay, M. D., Jenster, G., Lehman, M. L., Merkle, D., Tevz, G., van Leenders, G. J. L. H., van Strijp, D., Waanders, L. F.   +12 more
core   +1 more source

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
A Hainard, B Beutler, B Courtioux, B Namangala, CA Hunter, CA Hunter, CF Calvo, EN Benveniste, F Checchi, F Esamai, G Binz, H Reiber, H Reiber, H Reiber, Hansotto Reiber, HY Hassan, J Kabore, J Rodgers, Jeremy M. Sternberg, JM Sternberg, JM Sternberg, JM Sternberg, Joseph Mathu Ndung'u, KW Moore, L Maclean, L MacLean, L MacLean, L MacLean, LJ Morrison, LM MacLean, Lorna MacLean, M Sjogren, MC Okomo-Assoumou, P Cattand, PD Eckersall, Peter G. E. Kennedy, PG Kennedy, PGE Kennedy, PGE Kennedy, TN Baral, V Jamonneau, V Lejon, V Lejon, V Lejon, W Masocha   +44 more
core   +4 more sources

Statistical Disease Progression Modeling in Alzheimer Disease

Frontiers in Big Data, 2020
Background: The characterizing symptom of Alzheimer disease (AD) is cognitive deterioration. While much recent work has focused on defining AD as a biological construct, most patients are still diagnosed, staged, and treated based on their cognitive ...
L. L. Rakêt
semanticscholar   +1 more source

Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients [PDF]

The Korean Journal of Internal Medicine, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and
Yun Kyu Oh, Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Kook-Hwan Oh   +4 more
doaj   +1 more source