Results 61 to 70 of about 7,373,821 (305)

AD Course Map charts Alzheimer’s disease progression [PDF]

, 2021
International audienceAlzheimer's disease (AD) is characterized by the progressive alterations seen in brain images which give rise to the onset of various sets of symptoms.
Samper-González, Jorge, Colliot, Olivier, Koval, Igor, Bertrand, Anne, Epelbaum, Stéphane, Burgos, Ninon, Durrleman​, Stanley, Louis, Maxime, Charlier, Benjamin, Bône, Alexandre, Marcoux, Arnaud, Bottani, Simona, Lartigue, Thomas, Allassonnière, Stéphanie   +13 more
core   +1 more source

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression [PDF]

Trends in Immunology, 2008
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the
Hui-Ming, Gao, Jau-Shyong, Hong
openaire   +2 more sources

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Frontiers in Bioengineering and Biotechnology, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu, Qian Hu, Qian Hu, Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Leiyun Wang, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei, Jie Mei, Jie Mei, Peng-Yuan Wang   +15 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

The relationships between the HIV test interval, demographic factors and HIV disease progression [PDF]

, 2001
Individuals developing an HIV seroconversion illness may experience rapid disease progression. Information on seroconversion illness is rarely collected in most cohort studies; thus the aim of this study was to assess the value of the HIV test interval ...
Sabin, CA
core  

Vitamin D Status of HIV-Infected Women and its Association with HIV Disease Progression, Anemia, and Mortality. [PDF]

, 2010
Vitamin D has a potential role in slowing HIV disease progression and preventing mortality based on its extensive involvement in the immune system; however, this relationship has not been examined in large studies or in resource-limited settings. Vitamin
Mugusi, Ferdinand M, Mugusi, F.M, Hunter, D., Spiegelman Donna, Mehta, Saurabh, Hertzmark, E., Saurabh Mehta, Mugusi, Ferdinand M., Spiegelman, D., Fawzi, W.W, Hertzmark Ellen, Mugusi Ferdinand M., Edward Giovannucci, Wafaie W Fawzi, Fawzi, Wafaie, Spiegelman, Donna, Fawzi Wafaie W., Msamanga, G.I, Said Aboud, Giovannucci Edward, Hunter David, Aboud, Said, Hertzmark, Ellen, Giovannucci, E., Msamanga Gernard I., Ellen Hertzmark, Ferdinand M Mugusi, David Hunter, Mehta Saurabh, Aboud Said, Aboud, S., Msamanga, Gernard I., Hunter, David, Giovannucci, Edward, Msamanga, Gernard I, Donna Spiegelman, Gernard I Msamanga, Fawzi, Wafaie W   +37 more
core   +2 more sources

Cerebrospinal fluid inflammatory biomarkers for disease progression in Alzheimer’s disease and multiple sclerosis: a systematic review

Frontiers in Immunology, 2023
Inflammatory processes are involved in the pathophysiology of both Alzheimer’s disease (AD) and multiple sclerosis (MS) but their exact contribution to disease progression remains to be deciphered.
Joke Temmerman, Joke Temmerman, Joke Temmerman, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Maria Bjerke, Maria Bjerke, Maria Bjerke, Maria Bjerke, Miguel D’haeseleer, Miguel D’haeseleer, Miguel D’haeseleer   +12 more
doaj   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

Epitranscriptomic analysis reveals clinical and molecular signatures in glioblastoma

Acta Neuropathologica Communications
This study characterizes the glioblastoma (GB) epitranscriptomic landscape in patient who evolve to progressive disease (PD) or pseudo-progressive disease (psPD). Novel differences in N6-Methyladenosine (m6A) RNA methylation patterns between these groups
Glaucia Maria de Mendonça Fernandes, Wesley Wang, Saman Seyed Ahmadian, Daniel Jones, Jing Peng, Pierre Giglio, Monica Venere, José Javier Otero   +7 more
doaj   +1 more source

Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial

Renal Failure, 2021
Background Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerulonephritis worldwide, and the optimal approach to its treatment remains a significant challenge.
Zhaohui Ni, Zhen Zhang, Zanzhe Yu, Fuming Lu, Changlin Mei, Xiaoqiang Ding, Weijie Yuan, Wei Zhang, Gengru Jiang, Min Sun, Liqun He, Yueyi Deng, Huihua Pang, Jiaqi Qian   +13 more
doaj   +1 more source