Results 61 to 70 of about 3,107,227 (309)

Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry

Respiratory Research
Background The prognostic value of patterns and quantitative measures of lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary fibrosis (PPF) has not been established.
Aparna C. Swaminathan, Jeremy M. Weber, Jamie L. Todd, Scott M. Palmer, Megan L. Neely, Timothy P. Whelan, Grace Hyun J. Kim, Thomas B. Leonard, Jonathan Goldin   +8 more
doaj   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Frontiers in Bioengineering and Biotechnology, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu, Qian Hu, Qian Hu, Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Leiyun Wang, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei, Jie Mei, Jie Mei, Peng-Yuan Wang   +15 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Cerebrospinal fluid inflammatory biomarkers for disease progression in Alzheimer’s disease and multiple sclerosis: a systematic review

Frontiers in Immunology, 2023
Inflammatory processes are involved in the pathophysiology of both Alzheimer’s disease (AD) and multiple sclerosis (MS) but their exact contribution to disease progression remains to be deciphered.
Joke Temmerman, Joke Temmerman, Joke Temmerman, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Maria Bjerke, Maria Bjerke, Maria Bjerke, Maria Bjerke, Miguel D’haeseleer, Miguel D’haeseleer, Miguel D’haeseleer   +12 more
doaj   +1 more source

Model of host-pathogen Interaction dynamics links In vivo optical imaging and immune responses [PDF]

, 2016
Tracking disease progression in vivo is essential for the development of treatments against bacterial infection. Optical imaging has become a central tool for in vivo tracking of bacterial population development and therapeutic response.
Ale, A, Babtie, AC, Collins, Constantinou, N, Crepin, VF, Frankel, G, Habibzay, Stumpf, MP   +7 more
core   +2 more sources

Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial

Renal Failure, 2021
Background Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerulonephritis worldwide, and the optimal approach to its treatment remains a significant challenge.
Zhaohui Ni, Zhen Zhang, Zanzhe Yu, Fuming Lu, Changlin Mei, Xiaoqiang Ding, Weijie Yuan, Wei Zhang, Gengru Jiang, Min Sun, Liqun He, Yueyi Deng, Huihua Pang, Jiaqi Qian   +13 more
doaj   +1 more source

Discovery of a Novel Leaf Rust (Puccinia recondita) Resistance Gene in Rye (Secale cereale L.) Using Association Genomics

Cells, 2021
Leaf rust constitutes one of the most important foliar diseases in rye (Secale cereale L.). To discover new sources of resistance, we phenotyped 180 lines belonging to a less well-characterized Gülzow germplasm at three field trial locations in Denmark ...
Nikolaj Meisner Vendelbo, Khalid Mahmood, Pernille Sarup, Mogens S. Hovmøller, Annemarie Fejer Justesen, Peter Skov Kristensen, Jihad Orabi, Ahmed Jahoor   +7 more
doaj   +1 more source

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [PDF]

, 2010
Oxidative stress is proposed as an important factor in osteoarthritis (OA). To investigate the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
Boot-Handford, Raymond P., Clark, Ian M., Davidson, Rose K., Gabrielides, Christos, Kirkwood, Tom B. L., Scott, Jenny L., Swingler, Tracey E., Talyor, Robert W., Wallis, Gillian A., Young, David A.   +9 more
core   +1 more source

Progression of Liver Diseases [PDF]

Hepatitis Monthly, 2012
Dear Editor, To date, the knowledge on the natural history of HCV infection and the risk factors associated with progression of liver disease in children is limited. Progressive liver disease, including hepatocellular carcinoma, is rare but has been reported [1].
openaire   +2 more sources