Results 71 to 80 of about 12,637,526 (357)

Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease [PDF]

, 2016
The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD.
Heerspink, Hiddo J.L., Mischak, Harald, Pena, Michelle J.   +2 more
core   +2 more sources

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Nature Communications, 2019
Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium (mCa2+) signaling is ...
P. Jadiya, Devin W. Kolmetzky, D. Tomar, A. Di Meco, A. Lombardi, Jonathan P. Lambert, T. Luongo, M. H. Ludtmann, D. Praticò, J. Elrod   +9 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry

Respiratory Research
Background The prognostic value of patterns and quantitative measures of lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary fibrosis (PPF) has not been established.
Aparna C. Swaminathan, Jeremy M. Weber, Jamie L. Todd, Scott M. Palmer, Megan L. Neely, Timothy P. Whelan, Grace Hyun J. Kim, Thomas B. Leonard, Jonathan Goldin   +8 more
doaj   +1 more source

Serial intravascular ultrasound assessment of coronary atherosclerosis progression and remodeling [PDF]

, 2008
Cardiovascular disease is a major cause of morbidity and mortality in countries with western lifestyle. Reliable quantitative assessment of the extent of coronary atherosclerosis during the natural history of coronary artery disease and following ...
Hartmann, Marc
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Predicting the Progression of Very Early Systemic Sclerosis: Current Insights

Open Access Rheumatology: Research and Reviews, 2022
Chiara Bellocchi,1,2 Augustine Chung,3 Elizabeth R Volkmann4 1Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, University of Milan, Milan, Italy; 2Department of ...
Bellocchi C, Chung A, Volkmann ER
doaj  

Risk Prediction of a Multiple Sclerosis Diagnosis

, 2013
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The progression and severity of MS varies by individual, but it is generally a disabling disease.
Ghosh, Joydeep, Ho, Joyce C., Unnikrishnan, KP   +2 more
core   +1 more source

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Scientific Reports, 2019
Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by a decline in cognitive functions with no validated disease modifying treatment.
Garam Lee, K. Nho, Byungkon Kang, Kyung-ah Sohn, Dokyoon Kim, for the Alzheimer’s Disease Neuroimaging Initiative   +5 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source