Results 121 to 130 of about 692,625 (254)

How Everything Is Connected to Everything Else – Population‐Specific Connections between Adaptive Evolution, Disease Susceptibility, and Drug Responsiveness

Advanced Genetics
The genome is like a kaleidoscope through which researchers have obtained varied findings, including favored mutations, disease susceptibility sites, and drug‐responsive sites.
Ji Tang, Hao Zhu
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

A Systemic Review and Meta-analysis on Natural Resistance-associated Macrophage Protein 1 (3’-Untranslated Region) and Nucleotide-binding Oligomerization Domain-2 (rs8057341) Polymorphisms and Leprosy Susceptibility in Asian and Caucasian Populations

International Journal of Mycobacteriology
The current meta-analysis aims to explore the potential correlation between natural resistance-associated macrophage protein 1 (NRAMP1) (3’-Untranslated region [3’-UTR]) and nucleotide-binding oligomerization domain-2 (NOD2 [rs8057341]) gene ...
Bibin Savio Antony, Chitra Nagarajan, Danis Vijay Devaraj, Gowtham Kumar Subbaraj   +3 more
doaj   +1 more source

Evaluating Association between ABO Blood Groups and COVID 19

Medical Laboratory Journal, 2021
Introduction: COVID 19 pandemic caused by SARS-COV2 virus has taken a toll all over the world. The susceptibility of various diseases like Helicobacter Pylori, Hepatitis B virus and Norwalk Virus and even SARS Corona Virus 1 have been associated with ABO
Bhumika Gupta, Shivani Kalhan, Shalini Shukla, Shalini Bahadur, Gyanendra Singh, Rambha Pathak   +5 more
doaj  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The whole genome sequencing offers insights into the susceptibility to the foot-and-mouth disease virus carrier state

Veterinary Research
Foot-and-mouth disease virus (FMDV) establishes persistent infection in more than 50% of infected ruminants, irrespective of vaccination status, implicating potential contributions of host genetic variations to viral persistence.
Zhihui Zhang, Zhidong Teng, Shuanghui Yin, Suyu Mu, Sumin Wei, Yaozhong Ding, Yun Zhang, Shuang Wang, Yijing Li, Shiqi Sun, Huichen Guo   +10 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

COVID-19 Susceptibility among ABO/RH Blood Groups in Tamil Nadu Population: A Retrospective Case–Control Study

Journal of Indian Association of Public Health Dentistry
Background: COVID-19 is a world pandemic with clinical manifestation from mild subclinical infection to severe illness. Literature suggests an evident correlation between the ABO blood group, Rhesus blood group, and COVID-19 in the recent past.
Paavai Ilango, Sanjay M. Cherian, Arulpari Mahalingam, Vineela Katam Reddy, Ayswarya V. Vummidi, G.D Gomathi   +5 more
doaj   +1 more source

ABO Blood Group and the Risk and Prognosis of Lymphoma

Journal of Inflammation Research, 2023
Ling Qin,1 Dongli Gao,1 Qian Wang,1 Xuewei Zheng,2 Jingjing Wang,2 Xingang Chen,2 Dongliao Fu,2 Haodi Ma,2 Junjia Tan,3 Qinan Yin2 1The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang ...
Qin L, Gao D, Wang Q, Zheng X, Wang J, Chen X, Fu D, Ma H, Tan J, Yin Q   +9 more
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source