Results 111 to 120 of about 6,182,453 (264)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

SnTox3 acts in effector triggered susceptibility to induce disease on wheat carrying the Snn3 gene [PDF]

, 2009
The necrotrophic fungus Stagonospora nodorum produces multiple proteinaceous host-selective toxins (HSTs) which act in effector triggered susceptibility.
McDonald, B., McDonald Megan C., Nunez, A., Faris Justin D., Liu, Z., Zhaohui Liu, Friesen Timothy L., Tan, Kar-Chun, Oliver, R.P., Faris, Justin D., Kar-Chun Tan, Oliver, Richard P., Rasmussen, Jack B., Lu Shunwen, Solomon Peter S., Richard P Oliver, Friesen, T., Tan, K.C., Megan C McDonald, McDonald, M., Oliver Richard P., Bruce A McDonald, Friesen, T.L., Jack B Rasmussen, McDonald, Megan C., McDonald, Megan C.; id_orcid, Faris, J.D., Peter S Solomon, Liu Zhaohui, Nunez, Alberto, McDonald, Bruce A., Rasmussen, J., Rasmussen Jack B., Friesen, Timothy L., Faris, J., McDonald Bruce A., Oliver, Richard, Liu, Zhaohui, McDonald, B.A., Rasmussen, J.B., Nunez Alberto, Solomon, Peter S., Tan Kar-Chun, Timothy L Friesen, Solomon, P., McDonald, M.C., Lu, S., Shunwen Lu, Justin D Faris, Alberto Nunez, Lu, Shunwen, Solomon, P.S.   +51 more
core   +1 more source

Commentary: A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system

Acta Pharmaceutica Sinica B, 2023
Nan Ru, Wan-Yang Sun, Hua-Jun Wang, Yan-Ping Wu, Xiao-Fei Zheng, Rong-Rong He   +5 more
doaj   +1 more source

Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility

Evolutionary Applications, 2013
Variation in polyglutamine repeat number in the androgen receptor (AR CAGn) is negatively correlated with the transcription of androgen‐responsive genes and is associated with susceptibility to an extensive list of human disease.
Calen P. Ryan, Bernard J. Crespi
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Pervasive Sharing of Genetic Effects in Autoimmune Disease [PDF]

, 2011
Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated) diseases, some of which are shared ...
Klareskog, Lars, Benjamin F Voight, Worthington, Jane, Abecasis, Gonçalo R., David A van Heel, Judy Cho, Klareskog Lars, AbecasisGonç, Gonçalo R., Graham Robert R., van Heel, David A., Hansen, Kasper Lage, Graham, Robert R., Lage, Kasper, David A. van Heel, Hafler, David A., Benjamin M. Neale, Gregersen, Peter K., Gregersen, Peter, James T. Elder, Behrens Timothy, David A. Hafler, Siminovitch, Katherine A., null null, Philip L De Jager, Wijmenga, Cisca, Elizabeth Rossin, Cisca Wijmenga, David A Hafler, Chris Cotsapas, Siminovitch, KA, Kasper Lage, Mark J. Daly, Elder James T., Wallace Chris, John A. Todd, Hafler, DA, Rossin Elizabeth, Cotsapas, C, Gregersen Peter, Cotsapas, Chris, Klareskog, L, John A Todd, Behrens, Timothy, Rich Stephen S., Rich, Stephen S., Timothy Behrens, Todd, JA, Heel, David A. van, Abecasis Gonçalo R., Philip L. De Jager, Wallace, C, Neale, BM, Voight, BF, Voight, Benjamin F., Gonçalo R. Abecasis, Robert R. Graham, De Jager Philip L., Jeffrey C Barrett, Neale Benjamin M., Siminovitch Katherine A., Chris Wallace, Katherine A. Siminovitch, Benjamin M Neale, Robert R Graham, Cho, Judy, Jager, Philip L. De, Barrett Jeffrey C., Daly Mark J., Cotsapas Chris, Gonçalo R Abecasis, Rich, SS, van Heel David A., Wijmenga Cisca, Rossin, E, Graham, RR, Worthington, J, Gregersen, P, Barrett, Jeffrey C., Elder, James T., Jeffrey C. Barrett, Peter Gregersen, Katherine A Siminovitch, Lage Kasper, Wijmenga, C, Neale, Benjamin M., Wallace, Chris, Hafler David A., Behrens, T, James T Elder, Mark J Daly, Todd John A., Abecasis, GR, Elder, JT, Wijmenga, Cisca; id_orcid, Lars Klareskog, De Jager, PL, Voight Benjamin F., Benjamin F. Voight, FOCiS Network Consortia, Jane Worthington, Stephen S. Rich, Cho, J, FOCiS Network of Consortia, Cho Judy, Stephen S Rich, Barrett, JC, van Heel, DA, Todd, John A., Daly, Mark J., Daly, MJ, Worthington Jane, Rossin, Elizabeth, Lage, K, De Jager, Philip L.   +113 more
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Maltese with genetic susceptibility to poliomyelitis : sibs with paralysis at different times [PDF]

, 2015
The author of this article found the records of 1,072 Maltese cases of poliomyelitis in the islands of Malta from 1909 to 1964. These cases and baptism matched controls were traced to their great grand-parents and all marriages were checked for ...
Wyatt, H. V.
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

The whole genome sequencing offers insights into the susceptibility to the foot-and-mouth disease virus carrier state

Veterinary Research
Foot-and-mouth disease virus (FMDV) establishes persistent infection in more than 50% of infected ruminants, irrespective of vaccination status, implicating potential contributions of host genetic variations to viral persistence.
Zhihui Zhang, Zhidong Teng, Shuanghui Yin, Suyu Mu, Sumin Wei, Yaozhong Ding, Yun Zhang, Shuang Wang, Yijing Li, Shiqi Sun, Huichen Guo   +10 more
doaj   +1 more source