Results 91 to 100 of about 875,037 (313)

Disease susceptibility genes for autism

Annals of Medicine, 2003
Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic autism is estimated at over 90 ...
Irina N, Bespalova, Joseph D, Buxbaum
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Associative role of HLA-DRB1 as a protective factor for susceptibility and progression of Parkinson’s disease: a Chinese cross-sectional and longitudinal study

Frontiers in Aging Neuroscience
BackgroundPrevious genome-wide association studies investigating the relationship between the HLA-DRB1 and the risk of Parkinson’s disease (PD) have shown limited racial diversity and have not explored clinical heterogeneity extensively.MethodsThe study ...
Raoli He, Raoli He, Raoli He, Yuqi Zeng, Yuqi Zeng, Yuqi Zeng, Chaodong Wang, Lina Chen, Guoen Cai, Guoen Cai, Guoen Cai, Ying Chen, Ying Chen, Ying Chen, Yingqing Wang, Yingqing Wang, Yingqing Wang, Qinyong Ye, Qinyong Ye, Qinyong Ye, Xiaochun Chen, Xiaochun Chen   +21 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Some biological features of cherry leaf spot (Blumeriella jaapii) with special reference to cultivar susceptibility

International Journal of Horticultural Science, 2009
In this review, some important features of biology are summarised for cherry leaf spot (Blumeriella jaapii). In the first part of the review, the geographical distribution of the pathogen and the causal organism are described.
I. J. Holb
doaj   +1 more source

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases [PDF]

, 2015
Chrysanthi Skevaki, Michail V. Pararas, Kalliope Kostelidou, Athanasios Tsakris, John G. Routsias   +4 more
openalex   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Identification of Arabidopsis Loci Required for Susceptibility to the Downy Mildew Pathogen Hyaloperonospora parasitica

Molecular Plant-Microbe Interactions, 2005
Plants are susceptible to a limited number of pathogens. Most infections fail due to active defense or absence of compatibility. Many components of the plant's surveillance system and defense arsenal have been identified in the last decades.
Mireille Van Damme, Annemiek Andel, Robin P. Huibers, Ralph Panstruga, Peter J. Weisbeek, Guido Van den Ackerveken   +5 more
doaj   +1 more source

Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease [PDF]

, 2009
Rona K. Graham, Mahmoud A. Pouladi, Prasad Joshi, Ge Lu, Yu Deng, Nanping Wu, Bryan E. Figueroa, Martina Metzler, Véronique M. André, Elizabeth Slow, Lynn A. Raymond, Robert M. Friedlander, Michael S. Levine, Blair R. Leavitt, Michael R. Hayden   +14 more
openalex   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source