Results 201 to 210 of about 828,302 (264)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Sarbecovirus disease susceptibility is conserved across viral and host models. [PDF]

Virus Res
Leist SR, Schäfer A, Risemberg EL, Bell TA, Hock P, Zweigart MR, Linnertz CL, Miller DR, Shaw GD, de Villena FPM, Ferris MT, Valdar W, Baric RS.   +12 more
europepmc   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study. [PDF]

Nucleic Acids Res
Cao C, Shao M, Wang J, Li Z, Chen H, You T, Li MJ, Ding Y, Zou Q.   +8 more
europepmc   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility. [PDF]

Nat Commun
Gong J, Sun H, Wang K, Zhao Y, Huang Y, Chen Q, Qiao H, Gao Y, Zhao J, Ling Y, Cao R, Tan J, Wang Q, Ma Y, Li J, Luo J, Wang S, Wang J, Zhang G, Xu S, Qian F, Zhou F, Tang H, Li D, Chinese Pangenome Consortium (CPC), Sedlazeck FJ, Jin L, Guan Y, Fan S.   +28 more
europepmc   +1 more source

Whole-exome sequencing reveals Kawasaki disease susceptibility genes and their association with coronary artery lesion. [PDF]

Front Pediatr
Wang Y, Chen X, Zhang D, Chen R, Alifu A.   +4 more
europepmc   +1 more source

Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41-GDNF/RET/SOX10 signaling pathway. [PDF]

Imeta
Zhang C, Chen Y, Duan R, Zhang Y, Zheng H, Zhang J, Zhang T, Xu J, Li K, Pei F, Duan L.   +10 more
europepmc   +1 more source