Results 211 to 220 of about 692,625 (254)
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Aging and Susceptibility to Pulmonary Disease
Comprehensive Physiology, 2022Abstract The lungs are continually subjected to noxious and inert substances, are immunologically active, and are in a constant state of damage and repair. This makes the pulmonary system particularly vulnerable to diseases of aging.
Julia, Budde, Gwen, Skloot
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Obesity and susceptibility to autoimmune diseases
Expert Review of Clinical Immunology, 2011For decades, obesity has been considered to be the result of the complex interaction between genes and the environment and its pathogenesis is still unresolved. The discovery of hormones and neural mediators responsible for the control of food intake and metabolism at the hypothalamic level has provided fundamental insights into the complicated ...
Procaccini C +6 more
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Mendelian susceptibility to mycobacterial disease
Clinical Genetics, 2010The host response to mycobacterial infection is mediated by the type I cytokine pathway (cell-mediated immunity). Deficiencies in this response result in susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria.
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HLA and Susceptibility to Hodgkin's Disease
Immunological Reviews, 1983Strong arguments supporting a genetic linkage between susceptibility to HD and HLA are reported. These observations are based on data from 33 multiplex case families, gathered from international series and from our own studies. They confirm the disturbed segregation of HLA haplotypes among pairs of affected siblings (P less than 0.0005). An excess of a
J, Hors, J, Dausset
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HLA and Disease Susceptibility: A Primer
New England Journal of Medicine, 1977Several hundred papers, each reporting an increased frequency of one or more HLA antigens among patients with a particular human disease, have appeared in the medical literature in the last few yea...
L E, Rosenberg, K K, Kidd
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The HLA Polymorphism and Susceptibility to Disease
Vox Sanguinis, 1976Remarkable differences were observed when 1,465 healthy Caucasian individuals and 128 healthy Negro individuals were compared for the genetic distribution of 25 different HLA antigens. Caucasians had a significantly higher frequency of A1, A3, B8, and Bw16, and Negroes of A28 and Aw30.
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TLR4 polymorphisms and disease susceptibility
Inflammation Research, 2012Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal
Mamoona, Noreen +7 more
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Disease susceptibility, transplantation and the MHC
Immunology Today, 1995Abstract Since his early days in the laboratory of Peter Gorer in the 1950s. Professor Richard Batchelor's distinguished research career has encompassed transplantation, tolerance, the MHC and disease susceptibility.
A J, George, M A, Ritter, R I, Lechler
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Genetic susceptibility to Parkinson's disease
Neurology, 1991Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model.
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Genetic Susceptibility in Infectious Diseases
Biotechnology and Genetic Engineering Reviews, 2000The outcome of infectious disease varies tremendously between individuals due to a number of factors and may therefore be viewed by the geneticist as complex traits. The identification of genes which influence disease outcome is, at present, a resource-intensive project and therefore should not be undertaken without clear evidence, preferably from twin
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