Results 11 to 20 of about 296,939 (346)

From Genotype to Phenotype: How Enhancers Control Gene Expression and Cell Identity in Hematopoiesis

open access: yesHemaSphere, 2023
Blood comprises a wide array of specialized cells, all of which share the same genetic information and ultimately derive from the same precursor, the hematopoietic stem cell (HSC).
Roger Mulet-Lazaro, Ruud Delwel
doaj   +1 more source

A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies

open access: yesHemaSphere, 2023
Until a few years ago, the onset of acute myeloid leukemia (AML) was entirely ascribed to genetic lesions in hematopoietic stem cells. These mutations generate leukemic stem cells, which are known to be the main ones responsible for chemoresistance and ...
Chiara Tomasoni   +4 more
doaj   +1 more source

Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)

open access: yesNutrients, 2021
Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status ...
Limin Yang   +12 more
semanticscholar   +1 more source

Central nervous system cholesterol metabolism in health and disease

open access: yesIUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2022
Cholesterol is a ubiquitous and essential component of cellular membranes, as it regulates membrane structure and fluidity. Furthermore, cholesterol serves as a precursor for steroid hormones, oxysterol, and bile acids, that are essential for maintaining
W. Y. Ho, H. Hartmann, Shuo-Chien Ling
semanticscholar   +1 more source

Impact of SARS-CoV-2 infection on patients with hematological malignancies: a retrospective study

open access: yesHematology, 2023
Objectives This study aimed to evaluate the characteristics of patients with hematological malignancies (HM) and SARS-CoV-2 infection and analyze the risk factors of their severity and mortality.Methods A retrospective study including inpatients ...
Huihan Zhao   +5 more
doaj   +1 more source

Adult Incidence in the Russian European Arctic with Developed Mining and Metallurgical Industry (en)

open access: yesРоссийская Арктика, 2019
The purpose of the research. The research aims to assess the adult incidence within the mining complex in the Murmansk Region (the Russian Arctic). Materials and methods.
A. N. Nikanov   +4 more
doaj   +1 more source

Diseases of the poultry reproductive organs (Case study: Altai Region, Russia) [PDF]

open access: yesCaspian Journal of Environmental Sciences
We carried out a complex research on the determination of pathogenesis and etiology of diseases of egg-forming organs in laying hens in conditions of industrial breeding.
Sergey V. Fedotov   +2 more
doaj   +1 more source

The Condition of Water Resources of the Republic of Kalmykia as an Important Factor of the Population Health

open access: yesVestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 11. Estestvennye Nauki, 2014
Natural water supply of the Republic of Kalmykia does not meet the needs of industrial, agricultural and social needs. Kalmykia, due to its geographical position, is turned into the utilizer of chemically polluted waters and industrial effluents ...
Nastinova Galina Erdneevna   +1 more
doaj   +1 more source

Homeostasis as the Mechanism of Evolution. [PDF]

open access: yes, 2015
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
Torday, John S
core   +2 more sources

Cellular-Based Therapies in Systemic Sclerosis: From Hematopoietic Stem Cell Transplant to Innovative Approaches

open access: yesCells, 2022
Systemic sclerosis (SSc) is a systemic disease characterized by autoimmune responses, vasculopathy and tissue fibrosis. The pathogenic mechanisms involve a wide range of cells and soluble factors.
E. Xue   +5 more
semanticscholar   +1 more source

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