Results 31 to 40 of about 153,870 (258)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

First-in-human pharmacokinetic, safety, and preliminary efficacy of single- and multiple-dose FRSW117, a novel PEGylated recombinant factor VIII-Fc fusion protein with an extended half-life, in patients with severe hemophilia A

Haematologica
Not available.
Feng Xue, Shuxia Guo, Ping Liu, Weizhi Chen, Yun Chen, Qing Wen, Haiying Hua, Yu Cao, Xianqi Feng, Jing Sun, Chongyuan Xu, Renchi Yang   +11 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Blocking platelet glycoprotein V cleavage reduces bleeding in mouse models of MYH9-related disease

Haematologica
Not available.
Patricia Öftering, Juliane Baumann, Sarah Beck, Andreas Greinacher, Bernhard Nieswandt, Markus Bender   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Epstein–Barr virus reactivation after haplo-peripheral blood stem cell transplantation in patients with hematological malignancies: immune reconstitution and influence on survival

Therapeutic Advances in Hematology
Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a common alternative for patients with hematological malignancies. Epstein–Barr virus (EBV) reactivation is a common complication post-transplantation, but its impact on ...
Ling Ma, Ying Zhang, Ting Wang, Yu Cai, Jun Yang, Yin Tong, Chongmei Huang, Huiying Qiu, Kun Zhou, Xiaowei Xu, Jiahua Niu, Chang Shen, Xinxin Xia, Yu Wei, Jie Shao, Min Yang, Jingjing Cao, Xianmin Song, Liping Wan   +18 more
doaj   +1 more source

Blinatumomab and better BCR::ABL1 inhibition begets better bone marrow transplant outcomes

Haematologica
Not available.
Marlise R. Luskin, Jessica T. Leonard
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Interventional therapy for a case of Mycoplasma pneumoniae pneumonia complicated by upper extremity arterial embolism in a child: a case report

Thrombosis Journal
Background Mycoplasma pneumoniae pneumonia complicated with arterial embolism in children is rare but progresses rapidly, potentially leading to severe limb ischemia and disability.
Ziyuan Zhang, Yunchao Sun, Jianmin Wang, Xin Zhang, Na Guo, Shaolong Niu, Zening Ma   +6 more
doaj   +1 more source