Results 141 to 150 of about 147,162 (263)

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

Gastrointestinal Health: Clinical Research and Therapeutic Innovations. [PDF]

Life (Basel)
Scarlata GGM, Abenavoli L.
europepmc   +1 more source

Comparable Diagnostic Accuracy but Discordant Thresholds Between FibroTouch and FibroScan: A Biopsy‐Based Comparative Study

Portal Hypertension &Cirrhosis, EarlyView.
In this biopsy‐controlled study, FibroTouch and FibroScan demonstrated comparable diagnostic accuracy for liver fibrosis staging (AUROCs > 0.900), but FibroTouch required consistently higher stiffness thresholds. These discrepancies were more pronounced in patients with MAFLD, highlighting the need for device‐specific cutoffs to avoid misclassification.
Min Wang, You Deng, Guanhua Zhang, Xinyan Zhao, Xiaoming Wang, Xiaojuan Ou, Min Li, Hong Ma, Yu Wang   +8 more
wiley   +1 more source

Successful Endoscopic Direct Appendicitis Therapy (EDAT) for occult appendiceal perforation with abscess: a case report. [PDF]

BMC Gastroenterol
Zhou B, Ma Y, Li T.
europepmc   +1 more source

Immune escape mechanisms revealed by multifunctional nanoprobes targeting PD‐L1 in hepatic cancer progression

VIEW, EarlyView.
The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng, Liwen Jing, Yeda Chen, Shenggang Zhan, Feng Xiong, Wenbiao Chen   +5 more
wiley   +1 more source

The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank. [PDF]

J Nutr Health Aging
Huang W, Zhang S, Chen W, Wang W, Lin Y, Zhang S, Huang F.   +6 more
europepmc   +1 more source

Development and Validation of an Individualized Nomogram to Identify Undifferentiated‐Predominant Mixed‐Type Early Gastric Cancer

Journal of Digestive Diseases, EarlyView.
This study identified open‐type atrophic gastritis, flat or depressed morphology, faded appearance, tumor location on the greater curvature or anterior wall, xanthoma, and previous Helicobacter pylori eradication as independent risk factors for undifferentiated‐type‐predominant mixed‐type early gastric cancer (UM‐EGC).
Lin Lin Shao, Yu Miao Zheng, Qian Zhang, Chuan Guo Guo, Peng Li   +4 more
wiley   +1 more source

Implementation and Outcomes of a Standardized Multidisciplinary Treatment Outpatient Model in Two Pediatric Tertiary Hospitals. [PDF]

J Multidiscip Healthc
Wang M, Ye C, Gao X, Qian Y, Feng T, Shi Y.   +5 more
europepmc   +1 more source

Improving access to direct acting antivirals via a multimodal integrated care program in an addiction medicine clinic

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Injection drug use is a driver of hepatitis C virus (HCV) transmission, thus integrating HCV care into addiction care is likely necessary for HCV elimination. Here we describe how we integrated HCV care into our addiction medicine (AM) clinic and evaluate its effect on HCV treatment.
Arya Zandvakili, Joseph Rattenni, James Burton, Lakshmi Guduguntla, Marcus Osman, Sayeh Sabbagh, Stephan Arndt, Ben Miskle, Quanhathai Kaewpoowat, Michael Ohl, Andrea Weber, Alison Lynch   +11 more
wiley   +1 more source