Results 121 to 130 of about 106,055 (260)

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

iMeta, EarlyView.
Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome‐scale metabolic modeling, we investigated how microbial translocation along the oral–gut axis influences microbial metabolism at different cirrhosis severities.
Yi Jin, Frederick Clasen, Fernando Garcia‐Guevara, Sania Arif, Robert Schierwagen, Gholamreza Bidkhori, Michael Praktiknjo, Maximilian J. Brol, Frank E. Uschner, Florence A. Castelli, Nicolas Pons, Benoit Quinquis, Nathalie Galleron, Kevin Da Silva, Christophe Junot, Debbie L. Shawcross, David L. Moyes, Rajiv Jalan, S. Dusko Ehrlich, Vishal C. Patel, Jonel Trebicka, Saeed Shoaie   +21 more
wiley   +1 more source

Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta‐Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steatotic liver disease (SLD) is an unrecognized complication after pancreaticoduodenectomy (PD) and may affect nutrition and long‐term recovery. This meta‐analysis estimated the incidence of SLD after PD and identified its clinical and surgical risk factors.
Ronnakorn Kongsakon, Wasit Wongtrakul, Khemajira Karaketklang, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya   +4 more
wiley   +1 more source

Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study

, 2019
Background: Refractory coeliac disease type 2 is a rare subtype of coeliac disease with high mortality rates; interleukin 15 (IL-15) is strongly implicated in its pathophysiology.
DiMarino, Anthony, Schumann, Michael, Crespo, Laura, Raymond, Ralph, Roy Ariño, Garbiñe, Bouma, Gerd, Crowe, Sheila E., Leon, Francisco, Hadjivassiliou, Marios, van Gils, Tom, Hermine, Olivier, Tsuji, Wayne, Rounioja, Samuli, Llewellyn, Beth, Perez Maseda, Raquel, Meresse, Bertrand, Collin, Pekka, Trinquand, Amelie, Green, Peter H. R., Cellier, Christophe, Viiri, Keijo, Macintyre, Elizabeth, Byrnes, Valerie, Lundin, Knut E. A., Bontkes, Hetty, Jabri, Bana, Parnes, Jane R., Murray, Joseph, Kelly, Ciaran P., Bhagat, Govind, Palmer, Ashleigh, Blanchard, Anne, Khater, Sherine, Sanders, David, Vlad, George, Cerf-Bensussan, Nadine, Mulder, Chris J., Azizi, Michel, García-Hoz, Carlota, Butz, Eric, Bui, Jack, Malamut, Georgia   +41 more
core   +1 more source

Independent Prognostic Value of Natural Tooth Count Versus Posterior Teeth Occlusion in Resected Pancreatic Cancer

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Prognostic significance of preoperative patient‐related factors, including oral health status, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We evaluated the association between preoperative factors—particularly oral health parameters—and long‐term survival after curative PDAC resection.
Kaoru Seo, Kenichiro Uemura, Kenjiro Okada, Hiromi Nishi, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Yoshiaki Murakami, Hiroyuki Kawaguchi, Shinya Takahashi   +8 more
wiley   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

Disruption of the biorhythm in gastric epithelial cell triggers inflammation in Helicobacter pylori-associated gastritis by aberrantly regulating NFIL3 via CagA activated ERK-SP1 pathway

Cell Communication and Signaling
Helicobacter pylori (H. pylori) associated gastritis, marked by chronic gastric inflammation, heightens gastric cancer risk by fostering a malignancy-prone microenvironment.
Yongsheng Teng, Yipin Lv, Wanyan Chen, Fangyuan Mao, Liusheng Peng, He Huang, Haiyan Li, Liwei Shi, Quanming Zou, Yuan Zhuang, Wenqing Tian, Hong Guo   +11 more
doaj   +1 more source

Outcomes and adverse effects of teduglutide treatment with periodic withdrawal in pediatric short bowel patients

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives We evaluated the efficacy and safety of teduglutide in a real‐world cohort in which national reimbursement policies required treatment interruptions. The primary outcomes were reduction in parenteral support (PS) and treatment‐related adverse effects, and the secondary outcome was the impact of the mandated withdrawal periods ...
Riikka Gunnar, Annika Mutanen, Mikko P. Pakarinen, Laura Merras‐Salmio   +3 more
wiley   +1 more source

Updated ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease 2025

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To revise the 2018 European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies (ERNICA) clinical guideline for the management of rectosigmoid Hirschsprung's disease (HSCR) based on new evidence and evolving clinical priorities, ensuring continued relevance, trustworthiness, and consistency ...
Daniel Rossi, Willemijn Irvine, Anna Löf Granström, Annika Mutanen, Roel Bakx, Kristin Bjørnland, Duccio Cavalieri, Piotr Czauderna, Anne Dariel, Mark Ellebæk, Francesco Fascetti Leon, Fabio Fusaro, Dirk‐Jan Gloudemans, Marietta Jank, Peter Kolja Kvist, Martin Lacher, Annette Lemli, Lucas Matthyssens, Louise Montalva, Pedro Palazon, Alessio Pini Prato, Lucie Pos, Roxana Rassouli‐Kirchmeier, Konrad Reinshagen, Nagoud Schukfeh, Rony Sfeir, Olivia Spivack, Pernilla Stenström, Lovisa Telborn, Eelke Toxopeus, Alejandra Vilanova, Miriam Wilms, Rene Wijnen, Cornelius E. J. Sloots, Mikko Pakarinen, Tomas Wester   +35 more
wiley   +1 more source

Development and characterisation of an in vitro human gut model to study the biofilm mode of growth of clostridium difficile and the indigenous gut microbiota [PDF]

, 2013
Clostridium difficile infection (CDI) is associated with significant patient morbidity, mortality and financial burden. Until recently, antimicrobial treatment options were limited to metronidazole and vancomycin, but both agents are associated with ...
Crowther, Grace
core  

European Society for Paediatric Gastroenterology, Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition guidelines for treatment of functional constipation in children aged 0–18 years

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Functional constipation (FC) is common in childhood, significantly impacting quality of life. Since the 2014 international guideline, new evidence has been published, and methods on making guidelines have developed. This treatment guideline for FC in children aged 0–18 years is a collaborative effort of the European and North ...
Morris Gordon, Anna de Geus, Mary Boruta, Marcin Banasiuk, Marc Benninga, Osvaldo Borrelli, Anil Darbari, Dawn Dore‐Stites, Michelle Gould, Juliette Hawa, Kirsten Jones, Alexandra Kilgore, Hayat Mousa, Samuel Nurko, Nikhil Thapar, Julie Khlevner, Vasiliki Sinopoulou, Merit Tabbers   +17 more
wiley   +1 more source