Results 41 to 50 of about 106,055 (260)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Confocal endomicroscopy for evaluation of pancreatic cystic lesions: a systematic review and international Delphi consensus report

Endoscopy International Open, 2020
Background and study aims The aim of thi systematic review and consensus report is to standardize the practice of endoscopic ultrasound (EUS-guided needle-based confocal laser endomicroscopy (nCLE) for pancreatic cystic lesion (PCL) evaluation.
Bertrand Napoleon, Somashekar G. Krishna, Bruno Marco, David Carr-Locke, Kenneth J. Chang, Àngels Ginès, Frank G. Gress, Alberto Larghi, Kofi W. Oppong, Laurent Palazzo, Pradermchai Kongkam, Carlos Robles-Medranda, Divyesh Sejpal, Damien Tan, William R. Brugge   +14 more
doaj   +1 more source

Drugs for the treatment of ulcerative colitis on the pharmaceutical market of Ukraine

Фармацевтичний журнал, 2023
The prevalence of diseases of the digestive organs at the current stage of human development is extremely high, and their universally increasing incidence rate is estimated as an epidemic. In Ukraine, mortality from diseases of the digestive organs ranks
L. M. Palchak, O. S. Kukhtenko, V. M. Khomenko   +2 more
doaj   +1 more source

Devices for endoscopic hemostasis of nonvariceal GI bleeding (with videos)

VideoGIE, 2019
Background: Endoscopic intervention is often the first line of therapy for GI nonvariceal bleeding. Although some of the devices and techniques used for this purpose have been well studied, others are relatively new, with few available outcomes data ...
Mansour A. Parsi, MD, MPH, FASGE, Allison R. Schulman, MD, MPH, Harry R. Aslanian, MD, FASGE, Manoop S. Bhutani, MD, FASGE, Kuman Krishnan, MD, David R. Lichtenstein, MD, FASGE, Joshua Melson, MD, FASGE, Udayakumar Navaneethan, MD, Rahul Pannala, MD, MPH, FASGE, Amrita Sethi, MD, FASGE, Guru Trikudanathan, MD, Arvind J. Trindade, MD, Rabindra R. Watson, MD, John T. Maple, DO, FASGE   +13 more
doaj   +1 more source

Training in pediatric hepatology across Europe: a survey of the National Societies Network (2016-2019) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition

, 2022
BACKGROUND: The widely recognized burden of liver diseases makes training in pediatric hepatology (PH) imperative. The aim of this survey, which was part of a global survey on training in pediatric gastroenterology, hepatology and nutrition (PGHN) across
Veres, Gabor, Furlano, Raoul, I,, Mas, Emmanuel,, Orel, Rok,, Guarino, Alfredo, Kansu, Aydan, Orel, Rok, Posovszky, Carsten,, Hauer, Almuthe Christine,, Protheroe, Sue,, Mas, Emmanuel, Fotoulaki, Maria,, Fotoulaki, Maria, Koutri, Eleni,, Hoffman, Ilse,, Ribes-Koninckx, Carmen,, Karagianni, Maria-Vasiliki,, Georgieva, Miglena, Furlano, Raoul I., Roman, Enriqueta, Noni, Maria,, Escher, Johanna,, Hauer, Almuthe, Christine, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska,, Baker, Alastair, Veres, Gabor,, Georgieva, Miglena,, Bronsky, Jiri,, Guarino, Alfredo,, Protheroe, Sue, Ribes-Koninckxh, Carmen,, Papadopoulou, Alexandra, Karagianni, Maria Vasiliki, Urbonas, Vaidotas, Ribes-Koninckxh, Carmen, Kelly, Deirdre, Furlano, Raoul I.,, Kansu, Aydan,, Koutri, Eleni, Ribes-Koninckx, Carmen, Papadopoulou, Alexandra,, Wilschanski, Michael,, Tjesic-Drinkovic, Duska, Noni, Maria, Baker, Alastair,, Roman, Enriqueta,, Karagianni, Maria-Vasiliki, Furlano, Raoul, Furlano, Raoul I, Furlano, Raoul, I, Wilschanski, Michael, Bronsky, Jiri, Urbonas, Vaidotas,, Posovszky, Carsten, Hoffman, Ilse, Kelly, Deirdre,, Escher, Johanna   +57 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Comorbidity of syndrome of increased epithelial permeability

Клинический разбор в общей медицине, 2023
Syndrome of increased epithelial permeability is one of the most studied pathogenic syndromes in the 21st century. In the English literature, the term “the leaky gut syndrome” is widely used to refer to Syndrome of increased epithelial permeability.
Dmitry I. Trukhan, Evgeny N. Degovtsov , Alexander Yu. Novikov   +2 more
doaj   +1 more source

Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis

, 2018
Background: In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed European guidelines for the management of chronic pancreatitis using ...

core   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source