Results 61 to 70 of about 106,055 (260)

Risk factors for ulcerative colitis in children

open access: yesZdorovʹe Rebenka, 2020
Background. Inflammatory bowel disease is one of the pressing problems in pediatric gastroenterology, due to the rapid spread of this pathology, displacement in the onset of the disease at an early age of a child (the first three years of life), the ...
N.Yu. Bukulova
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

open access: yesAdvanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu   +10 more
wiley   +1 more source

Influence du sevrage précoce sur la sensibilité des lapereaux à une infection expérimentale par une souche d'Escherichia coli entéropathogène O103:H2 [PDF]

open access: yes, 2005
La période du péri-sevrage en production cunicole est particulièrement difficile à gérer pour les éleveurs qui doivent concilier les impératifs de gestion et une sensibilité accrue des lapereaux aux infections notamment digestives.
Coudert, Cécile
core  

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

open access: yesAdvanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang   +19 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Indices of heart rate variability for estimation of adaptive processes and stress resistance in gastroenterology practice (using up-to-date technology of precise-diagnosis)

open access: yesGastroenterologìa, 2020
A vast amount of works is devoted to studying the heart rate variability (HRV). The article covers a literature review on modern concepts about heart rate variability as a method for estimation of mechanisms of physiological functions regulation in a ...
Yu.M. Stepanov, E.V. Zyhalo
doaj   +1 more source

O-25 ASSESSMENT OF MODELS FOR PREDICTING RESPONSE TO CORTICOIDS TREATMENT IN ALCOHOL-ASSOCIATED HEPATITIS: A GLOBAL COHORT STUDY

open access: yesAnnals of Hepatology, 2023
Introduction and Objectives: Alcohol-associated hepatitis (AH) is a severe entity associated with high mortality. Corticosteroids might be used in cases with severe disease and several dynamic models can predict mortality and response to corticosteroids ...
Francisco Idalsoaga   +63 more
doaj   +1 more source

Small bowel imaging in managing Crohn's Disease patients [PDF]

open access: yes, 2012
The small bowel is essential to sustain alimentation and small bowel Crohn's disease (CD) may severely limit its function. Small bowel imaging is a crucial element in diagnosing small bowel CD, and treatment control with imaging is increasingly used to ...
Albert, Jörg Gerhard, Jörg G. Albert
core   +1 more source

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

open access: yesAdvanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang   +10 more
wiley   +1 more source

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