Results 81 to 90 of about 108,553 (222)

The Role of Motility Impairment in the Pathogenesis of Functional Disorders of the Gastrointestinal Tract and Modern Possibilities for Their Treatment (Resolution of an Expert Council and Literature Review)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2020
Aim. To present the materials of an Expert Council, which was held on September 23, 2019 in Istanbul (Turkey) under the auspices of a World Gastroenterology Organisation congress and the support of the Abbott company.General provisions.
I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, V. I. Simanenkov, S. R. Abdulhakov, N. A. Agafonova, V. A. Akhmedov, T. A. Ilchishina, M. G. Ipatova, O. V. Krapivnaya, Yu. A. Kucheryavyi, M. F. Osipenko, O. A. Storonova, G. N. Tarasova, G. Ya. Khismatullina, S. V. Cheryomushkin   +15 more
doaj   +1 more source

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Dissecting the immunosuppressive microenvironment of LAMA3 + malignant cells and SPP1 + macrophages in esophageal squamous cell carcinoma using single-cell and spatial transcriptomics

Journal of Translational Medicine
Background Esophageal squamous cell carcinoma (ESCC) exhibits pronounced tumor microenvironment (TME) heterogeneity, which contributes to tumor invasion, immune evasion, and resistance to therapy. However, the cellular and spatial mechanisms driving this
Kunqiao Hong, Chengzhou Pa, Yijie Zhu, Yunrui Dai, Jialong Qi, Ping Wan   +5 more
doaj   +1 more source

Citrulline Inhibits Clostridioides difficile Infection With Anti-inflammatory EffectsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Clostridioides difficile infection (CDI) causes colitis and diarrhea. C. difficile bacterium produces toxins A and B, which cause intestinal inflammation.
Ying Xie, Sophie Irwin, Becca Nelson, Mieke van Daelen, Lindsey Fontenot, Jonathan P. Jacobs, Monica Cappelletti, Hanping Feng, Yiling Li, Hon Wai Koon   +9 more
doaj   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

Pediatric Human Olfactory Epithelium Mirrors Adult Structure and Function in a Human Olfactory Organoid Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objective This study investigated the developmental differences in structure, gene expression, and function of human olfactory epithelium (OE) using pediatric and adult specimens and human olfactory organoids. Background Olfactory dysfunction (OD) is characterized by loss or alterations in the sense of smell and has an age‐related increase in ...
Randy Bach, Ankit Chauhan, Michael Xiang, Kang‐Hoon Kim, James N. Palmer, Nithin D. Adappa, Michael A. Kohanski, Noam A. Cohen, Hong Wang, Jennifer E. Douglas   +9 more
wiley   +1 more source

Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway

Animal Models and Experimental Medicine, EarlyView.
This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu, Chen Wang, Hui‐Min Tao, Jin Huang, Wei‐Qin Li, Zhi‐Ning Fan   +5 more
wiley   +1 more source

CD47: an immunoregulatory nexus in liver and gastrointestinal disorders

eGastroenterology
Cluster of differentiation 47 (CD47) is a widely expressed transmembrane protein that serves as a critical immunoregulatory checkpoint in both homeostatic and pathological conditions of the digestive system.
Shuxia Wang, Josephine Otuagomah, Alana Newcomb, Taesik Gwag   +3 more
doaj   +1 more source

Bariatric-induced microbiome changes alter MASLD development in association with changes in the innate immune system

Frontiers in Microbiology
IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly 25% of the population and is the leading cause for liver-related mortality. Bariatric surgery is a well-known treatment for MASLD and obesity.
Simer Shera, William Katzka, Julianne C. Yang, Candace Chang, Nerea Arias-Jayo, Venu Lagishetty, Venu Lagishetty, Anna Balioukova, Anna Balioukova, Yijun Chen, Yijun Chen, Erik Dutson, Erik Dutson, Zhaoping Li, Zhaoping Li, Emeran A. Mayer, Emeran A. Mayer, Emeran A. Mayer, Joseph R. Pisegna, Joseph R. Pisegna, Claudia Sanmiguel, Claudia Sanmiguel, Claudia Sanmiguel, Shrey Pawar, David Zhang, Madelaine Leitman, Laura Hernandez, Jonathan P. Jacobs, Jonathan P. Jacobs, Jonathan P. Jacobs, Jonathan P. Jacobs, Tien S. Dong, Tien S. Dong, Tien S. Dong, Tien S. Dong   +34 more
doaj   +1 more source