Results 91 to 100 of about 106,055 (260)

Dissecting the immunosuppressive microenvironment of LAMA3 + malignant cells and SPP1 + macrophages in esophageal squamous cell carcinoma using single-cell and spatial transcriptomics

Journal of Translational Medicine
Background Esophageal squamous cell carcinoma (ESCC) exhibits pronounced tumor microenvironment (TME) heterogeneity, which contributes to tumor invasion, immune evasion, and resistance to therapy. However, the cellular and spatial mechanisms driving this
Kunqiao Hong, Chengzhou Pa, Yijie Zhu, Yunrui Dai, Jialong Qi, Ping Wan   +5 more
doaj   +1 more source

Citrulline Inhibits Clostridioides difficile Infection With Anti-inflammatory EffectsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Clostridioides difficile infection (CDI) causes colitis and diarrhea. C. difficile bacterium produces toxins A and B, which cause intestinal inflammation.
Ying Xie, Sophie Irwin, Becca Nelson, Mieke van Daelen, Lindsey Fontenot, Jonathan P. Jacobs, Monica Cappelletti, Hanping Feng, Yiling Li, Hon Wai Koon   +9 more
doaj   +1 more source

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

British Journal of Clinical Pharmacology, EarlyView.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa, Daiki Tsuji, Masahiro Hatori, Kazuyoshi Kawakami, Masahiko Nakao, Takuya Yano, Yuichiro Arakawa, Keisuke Matsuo, Yasukata Ohashi, Masato Ozaka, Naoki Sasahira, Yasuhiko Sakata, Yuki Kogure, Shinya Tamaki, Atsushi Wada, Yusuke Taki, Wataru Suzuki, Kazuo Kobayashi, Hiroshi Ishii, Kunihiko Itoh, Masakazu Yamaguchi, Kenichi Suzuki   +21 more
wiley   +1 more source

Autoimmune Diseases of Digestive Organs—A Multidisciplinary Challenge: A Focus on Hepatopancreatobiliary Manifestation

, 2021
It is well known that some pathological conditions, especially of autoimmune etiology, are associated with the HLA (human leukocyte antigen) phenotype.
Tomas Andrasina, Petr Jabandziev, Jitka Vaculova, Zdenek Kala, Jan Trna, Petr Dite, Lumir Kunovsky, Matej Hrunka, Martina Bojkova   +8 more
core   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Elimination of Fusobacterium nucleatum With Biomimetic Nanoparticles to Reverse Tumor Immunosuppression and Enhance Colorectal Cancer Therapy

Exploration, EarlyView.
Tumor‐related pathogenic bacteria can affect the treatment efficiency of tumors. Therefore, we have designed a nanoparticle that can accurately target tumor cells and related pathogenic bacteria, reverse the immunosuppressive effect of pathogenic bacteria on tumors, and synergistically enhance tumor treatment efficiency through sonodynamic therapy ...
Mengting Zhou, Jiahao Du, Cheng Li, Yefei Zhu, Kairuo Wang, Keyi Wen, Yuanyuan Zhang, Sy‐Tsong Dean Chueng, Qian Chen, Yang Zhang, Huanlong Qin   +10 more
wiley   +1 more source

Anatomical Understanding and Evolution of Surgical Treatment for Cancer of the Esophagogastric Junction: From Anatomical Controversies to Precision Surgery

Gut Medicine, EarlyView.
ABSTRACT The incidence of cancer of the esophagogastric junction (EGJC) has surged globally. Historically, its unique anatomical position and dual histological characteristics generated significant controversy regarding tumor classification and surgical strategies.
Cien Sun, Hao Liu, Dehua Ma, William C. Cho, Pasan Witharana, Jianfei Shen   +5 more
wiley   +1 more source

CD47: an immunoregulatory nexus in liver and gastrointestinal disorders

eGastroenterology
Cluster of differentiation 47 (CD47) is a widely expressed transmembrane protein that serves as a critical immunoregulatory checkpoint in both homeostatic and pathological conditions of the digestive system.
Shuxia Wang, Josephine Otuagomah, Alana Newcomb, Taesik Gwag   +3 more
doaj   +1 more source

The Roads of Rome for Functional Dyspepsia: From Rome I to Rome V

Gut Medicine, EarlyView.
ABSTRACT Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. Its diagnostic, classificatory, and therapeutic concepts have continuously evolved alongside successive iterations of the Rome diagnostic criteria, undergoing profound changes over more than three decades.
Zi‐xing Qian, Wei Wei
wiley   +1 more source

Impact of Gut Microbiota Metabolites on Serotonin Levels in Irritable Bowel Syndrome

Gut Medicine, EarlyView.
ABSTRACT Gut microbiota and their metabolites have been proposed as possible etiological factors in irritable bowel syndrome (IBS), and studies suggest that IBS is associated with impaired serotonin synthesis and release. Microbial metabolites are produced through biological pathways and enzymatic processes via gut microbiota.
Ning Gao, Yu Liu, Shaoxin Sun, Lulu Bin, Shanshan Li, Tao Yang, Winson Fu Zun Yang, Jiani Wu   +7 more
wiley   +1 more source