Results 71 to 80 of about 337,766 (290)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Economic evaluation in intensive care: The case of SDD [PDF]
, 1995 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this thesis was to examine the use of modelling techniques in the economic evaluation of selective decontamination of the digestive tract (SDD ...
Elliott, Rachel, Elliott, R
core
Chinese Medical Journal. Background:. Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on the burden of digestive system diseases in China are lacking.
Zhiyuan Cheng +11 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Hyperglycemia-induced attenuation of rectal perception depends upon pattern of rectal balloon inflation. Digestive Diseases and Sciences [PDF]
, 1997 This study investigated the effects of acute hyperglycemia on conscious rectal perception in response to two different rectal distension paradigms. Eleven healthy males were studied in random order on two separate days during euglycemia and hyperglycemia
core +1 more source
Puerarin: a hepatoprotective drug from bench to bedside
Chinese MedicinePueraria is a time-honored food and medicinal plant, which is widely used in China. Puerarin, the main component extracted from pueraria, has a variety of pharmacological characteristics.
Yi-Xiang He +9 more
doaj +1 more source
Frontiers in ImmunologyBackgroundDistant metastasis remains a major reason for the high recurrence and mortality of colorectal cancer (CRC). However, the underlying molecular mechanisms driving metastasis in CRC remain poorly understood.
Xiaotian Song +11 more
doaj +1 more source
DISEASES OF THE DIGESTIVE SYSTEM: PRIMARY DISABLEMENT IN THE IRKUTSK REGION
Acta Biomedica Scientifica, 2017 Materials and methods. The population-based cohort analysis was performed of the database of primary disabled in Irkutsk region due to the DDS for the period of 2013-2015. Morbidity rate of primary disablement was calculated for 10 000 of the population;
I. L. Petrunko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source