Results 61 to 70 of about 337,766 (290)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Influence du sevrage précoce sur la sensibilité des lapereaux à une infection expérimentale par une souche d'Escherichia coli entéropathogène O103:H2 [PDF]

, 2005
La période du péri-sevrage en production cunicole est particulièrement difficile à gérer pour les éleveurs qui doivent concilier les impératifs de gestion et une sensibilité accrue des lapereaux aux infections notamment digestives.
Coudert, Cécile
core  

Digestive System Diseases, Genetic Risk, and Incident Dementia : A Prospective Cohort Study [PDF]

Introduction: Although digestive system disease affects gut microbiota and their metabolites associated with dementia risk, the association between digestive system diseases and incident dementia has not yet been established.Methods: This cohort analysis
Kivipelto, Miia,, Ludvigsson, Jonas F, Larsson, Susanna C, Zhao, Jianhui,, Zhao, Jianhui, Kivipelto, Miia, Chen, Jie,, Ludvigsson, Jonas F.,, Chen, Jie, Dan, Lintao,, Yuan, Shuai,, Wu, Jing, Zhang, Yao,, Li, Xue, Dan, Lintao, Yuan, Shuai, Zhang, Yao, Li, Xue,, Larsson, Susanna C.,, Wu, Jing,   +19 more
core   +1 more source

Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms [PDF]

, 2023
ObjectivesDigestive system diseases have evolved into a growing global burden without sufficient therapeutic measures. Lactobacillus reuteri (L.
Yizhe Ma, Zichen Luo, Zhimin Xu, Yijing Peng, Yifan Jiang, Renqiang Yu   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway

Frontiers in Nutrition
IntroductionAlcoholic liver disease (ALD) is a pathological state of the liver caused by longterm alcohol consumption. Recent studies have shown that the modulation of the gut microbiota and its metabolic products, specifically the short-chain fatty ...
Mingyun Tang, Mingyun Tang, Long Zhao, Long Zhao, Fuchun Huang, Fuchun Huang, Tiangang Wang, Tiangang Wang, Xu Wu, Shanshan Chen, Shanshan Chen, Juan Fu, Juan Fu, Chaoli Jiang, Chaoli Jiang, Shulin Wei, Shulin Wei, Xuseng Zeng, Xuseng Zeng, Xiaoling Zhang, Xiaoling Zhang, Xin Zhou, Xin Zhou, Mei Wei, Zhi Li, Zhi Li, Zhi Li, Guohui Xiao, Guohui Xiao   +28 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Understanding the treatment of acute pancreatitis and its complications -a database for assessing traditional Chinese medicine use

Frontiers in Pharmacology
IntroductionIntegrative medicine combining traditional Chinese medicine (TCM) with biomedicine has become a notable approach for treating acute pancreatitis (AP).
Xin Zhou, Xin Zhou, Yu Yang, Ya-Li Liu, Ya-Li Liu, Wei-An Hao, Wei-An Hao, Xin-Yi Ao, Xin-Yi Ao, Jian-Qin Liu, Jian-Qin Liu, Yang Zhang, Zhi Li, Zhi Li, Zhi Li   +14 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Dynamics of prevalence of diseases of the digestive system among the population of different age groups in conditions of social stress [PDF]

, 2018
Objective: to analyze the prevalence of digestive diseases during social stress among the population of different age groups (young, mature, elderly / old). Material and Methods.
Lipatova TE, Denisova TP, Tyultyaeva LA, Kovalev EP.   +3 more
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