Results 41 to 50 of about 335,393 (290)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms

Frontiers in Pharmacology
Dachengqi decoction (DCQD) is a traditional Chinese medicine formula consisting of three botanical drugs and one mineral drug. It has anti-inflammatory, gastrointestinal motility, and microcirculation improvement effects.
Wen Guo, Wen Guo, Xiaobin Zhang, Xiaobin Zhang, Xin Zhou, Xin Zhou, Wangpeng Lan, Wangpeng Lan, Jianqin Liu, Yali Liu, Yali Liu, Li Li, Li Li, Zhi Li, Zhi Li, Zhi Li   +15 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Relationship between Serum Zinc Level and Liver Elastrography Using Fibroscan in Non-Alcoholic Fatty Liver Patients

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018
BACKGROUND AND OBJECTIVE: Zinc is one of the essential elements for many vital functions of the body, including regulation of gene expression, anti-inflammatory and antioxidant activity, protein and nucleic acids metabolism.
E Hajiani, A Parsi, K Erfanian Taghvaie, M Morvaridi   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Update on the Role of Rifaximin in Digestive Diseases. [PDF]

, 2023
Various environmental factors affecting the human microbiota may lead to gut microbial imbalance and to the development of pathologies. Alterations of gut microbiota have been firmly implicated in digestive diseases such as hepatic encephalopathy ...
Moreira, Leticia, Amieva Balmori, Mercedes, Surdea-Blaga, Teodora, Cravo, Marília, Balmori, Mercedes Amieva, Lukas, Milan, Berzigotti, Annalisa, Remes-Troche, José María, Romero-Gómez, Manuel, Gonçalves, Tiago Cúrdia, Gasbarrini, Antonio, Dumitrascu, Dan Lucian, Gombošová, Laura, Pietrzak, Anna, Juricek, Radovan, Tikhonov, Igor N., Ponziani, Francesca Romana, Neubauer, Katarzyna, Trna, Jan, Ianiro, Gianluca, Bakulin, Igor, Hamzaoui, Lamine, Tikhonov, Igor N   +22 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Research trends on traditional Chinese medicine and acute pancreatitis: A bibliometric analysis from 2007 to mid-2023

Heliyon
Background: Traditional Chinese Medicine (TCM) is a unique medical system of historic significance, holding substantial influence within China and beyond. In recent years, the efficacy of TCM in treating acute pancreatitis has been substantiated. Despite
Wang-peng Lan, Wen Guo, Xin Zhou, Zhi Li
doaj   +1 more source

Influence du sevrage précoce sur la sensibilité des lapereaux à une infection expérimentale par une souche d'Escherichia coli entéropathogène O103:H2 [PDF]

, 2005
La période du péri-sevrage en production cunicole est particulièrement difficile à gérer pour les éleveurs qui doivent concilier les impératifs de gestion et une sensibilité accrue des lapereaux aux infections notamment digestives.
Coudert, Cécile
core