Results 41 to 50 of about 340,222 (255)

LncRNA AP003469.2 promotes hepatocellular carcinoma progression by regulating cuproptosis via the miR-4732-3p/LIPT1 axis

Frontiers in Oncology
BackgroundHepatocellular carcinoma (HCC) is a malignant tumor characterized by high recurrence and metastasis rates, as well as a poor prognosis. Cuproptosis is a form of programmed cell death driven by abnormal copper-ion metabolism.
Jinlong Huo, Shuman Kuang, Shuman Kuang, Lin Wu, Lin Wu, Dong Ou   +5 more
doaj   +1 more source

METABOLIC SYNDROME AND METABOLISM-ASSOCIATED DISEASES OF THE DIGESTIVE SYSTEM

Медицинский совет, 2017
The article described a typical clinical situation that is frequently observed in the pediatric practice and probably will be more prevalent as the incidence of the metabolic syndrome continues to grow.
N. I. Ursova
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Role of yoga in the management of digestive system disorders

Environment Conservation Journal, 2017
A healthy digestive system is the key to total health. Digestive system diseases contribute a big proportion of all pathologies. Yoga is being recognised worldwide as the solution to these problems.
Manorma Singh
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Infectious and Non-infectious Diseases of the Digestive System. Epidemiological Interrelation

Эпидемиология и вакцинопрофилактика, 2019
Background. Infectious and non-infectious diseases of the digestive system are common in Russia and worldwide and have major social and economic significance, yet the importance of infectious diseases in development of chronic digestive disorders is not ...
M. O. Antipov, A. Ya. Mindlina
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway

Frontiers in Nutrition
IntroductionAlcoholic liver disease (ALD) is a pathological state of the liver caused by longterm alcohol consumption. Recent studies have shown that the modulation of the gut microbiota and its metabolic products, specifically the short-chain fatty ...
Mingyun Tang, Mingyun Tang, Long Zhao, Long Zhao, Fuchun Huang, Fuchun Huang, Tiangang Wang, Tiangang Wang, Xu Wu, Shanshan Chen, Shanshan Chen, Juan Fu, Juan Fu, Chaoli Jiang, Chaoli Jiang, Shulin Wei, Shulin Wei, Xuseng Zeng, Xuseng Zeng, Xiaoling Zhang, Xiaoling Zhang, Xin Zhou, Xin Zhou, Mei Wei, Zhi Li, Zhi Li, Zhi Li, Guohui Xiao, Guohui Xiao   +28 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Understanding the treatment of acute pancreatitis and its complications -a database for assessing traditional Chinese medicine use

Frontiers in Pharmacology
IntroductionIntegrative medicine combining traditional Chinese medicine (TCM) with biomedicine has become a notable approach for treating acute pancreatitis (AP).
Xin Zhou, Xin Zhou, Yu Yang, Ya-Li Liu, Ya-Li Liu, Wei-An Hao, Wei-An Hao, Xin-Yi Ao, Xin-Yi Ao, Jian-Qin Liu, Jian-Qin Liu, Yang Zhang, Zhi Li, Zhi Li, Zhi Li   +14 more
doaj   +1 more source