Results 21 to 30 of about 340,222 (255)
The pathophyiological role of aminoacyl-tRNA synthetases in digestive system diseases
Frontiers in Physiology, 2022 Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate transfer RNAs and are indispensable enzymes for protein biosynthesis in all the cells.
Wugelanmu Wusiman +3 more
doaj +1 more source
Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham +7 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
SLC25 in intestinal inflammation: mechanisms, pathological roles, and therapeutic implications
Frontiers in ImmunologyInflammatory bowel diseases (IBD) represent a spectrum of chronic gastrointestinal disorders fueled by a complex multifactorial interplay, where mitochondrial dysfunction has emerged as a critical contributor.
Juan Xu +13 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Diseases of the digestive system
Kazan medical journal, 1934 In the preface to his book, Prof. R.A. Luria writes: "Diseases of the digestive organs are undoubtedly the most frequent diseases with which the therapist has to deal. It is impossible not to agree with this, as well as with the idea that this area of internal medicine is the least familiar to a wide range of physicians.
openaire +1 more source
Common molecular basis for MASH and hepatitis C revealed via systems biology approach
Frontiers in OncologyBackgroundMetabolic dysfunction-associated steatohepatitis (MASH) is characterized by liver inflammation and damage caused by a buildup of fat in the liver.
Yongwei Cheng +10 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018 BACKGROUND AND OBJECTIVE: Zinc is one of the essential elements for many vital functions of the body, including regulation of gene expression, anti-inflammatory and antioxidant activity, protein and nucleic acids metabolism.
E Hajiani +3 more
doaj