Results 81 to 90 of about 1,195,331 (367)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Comparative analysis of immunity system indicators among patients with infectious diseases of the respiratory system

Aktualʹnaâ Infektologiâ, 2019
The article provides data on the relevance of acute respiratory diseases and pneumonia among militaries. The purpose of this work was to study the status of the immune system in military personnel during anti-terrorist operation, patients with acute ...
O.A. Raksha-Slіusareva, V.I. Trykhlib, O.A. Slіusarev, I.A. Tarasova, V.V. Alekseenko   +4 more
doaj   +1 more source

Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US ‘hot spot’

Annals of the Rheumatic Diseases, 2020
Objective To investigate differences in manifestations and outcomes of coronavirus disease 2019 (COVID-19) infection between those with and without rheumatic disease.
K. D’Silva, Naomi Serling-Boyd, Rachel S Wallwork, T. Hsu, Xiaoqing Fu, E. Gravallese, Hyon K. Choi, J. Sparks, Z. Wallace   +8 more
semanticscholar   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Rule-Out Outbreak: 24-Hour Metagenomic Next-Generation Sequencing for Characterizing Respiratory Virus Source for Infection Prevention

Journal of the Pediatric Infectious Diseases Society, 2017
Background. Metagenomic next-generation sequencing (mNGS) has been used to uncover unusual causes of infectious diseases but has not been used routinely for the investigation of putative nosocomial outbreaks.
Alexander L. Greninger, A. Waghmare, A. Adler, X. Qin, J. Crowley, J. Englund, J. Kuypers, K. Jerome, D. Zerr   +8 more
semanticscholar   +1 more source

Prescribing antibiotics to preschool children in primary health care in Croatia [PDF]

, 2008
The use of antibiotics depends on cultural and socioeconomic factors, physician's characteristics as well as on microbiological considerations. Aim of our study was to asses antibiotic prescription among preschool children in primary health care in ...
Bergman-Marković, Biserka, Blažeković-Milaković, Sanja, Matijašević, Ivana, Stojanović-Špehar, Stanislava, Vrca-Botica, Marija   +4 more
core  

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Hyperpolarized 129Xe NMR/MRI is a useful method for diagnosis of diseases of the respiratory system. However, the sensitive detection of specific compounds in blood remains a challenge because of the weak 129Xe signal in aqueous solution. We
Qingbin Zeng, Binglin Bie, Qianni Guo, Yaping Yuan, Qi Han, Xiaocang Han, Mingwei Chen, Xu Zhang, Yunhuang Yang, Maili Liu, Pan Liu, Hexiang Deng, Xin Zhou   +12 more
semanticscholar   +1 more source

Computational analysis of the behavior of atmospheric pollution due to demographic, structural factors, vehicular flow and commerce activities [PDF]

, 2019
According to the latest assessments made by the world health organization (WHO2016), the atmospheric pollution (air), has become one of the main causes of morbidity and mortality in the world, with a steep growth of respiratory diseases, increase in lung
Chakir, R., Hoyos, J. D., Niño, J. A., Streichenberger, B., Suárez, G.   +4 more
core