Results 41 to 50 of about 162,701 (253)

3D Printed Photon Shield Assembly for Low‐Noise Visual Stimulation During Two‐Photon Imaging in Mice

Advanced Materials Technologies, EarlyView.
We present the Photon Shield, an open‐hardware system for low‐noise two‐photon calcium imaging during visual stimulation in mice. Combining a 3D‐printed headplate and rail‐mounted shield substantially reduces stray‐light contamination, as quantitatively verified. Functional validation confirms reliable cortical responses. Open design files enable broad
Gergely Katona, Andrea Slézia, András Dávid, Ábel Petik, Dániel Hillier, István Ulbert, Attila Kaszás   +6 more
wiley   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Effect of 6S refined individualized nursing management in the perioperative period of Parkinson’s disease patients undergoing deep brain stimulation

Frontiers in Neurology
AimThis study aimed to investigate whether Sort, Set in order, Shine, Standardize, Sustain, and Safety (6S) refined individualized nursing management improves perioperative outcomes in patients with Parkinson’s disease (PD) undergoing deep brain ...
Yunhui Luo, Fang Guo, Jing Bai, Xuan Li, Jinghua Bei, Yujing Xing, Feng Zhang   +6 more
doaj   +1 more source

Spatiotemporal patterns and meteorological associations of mosquito density: insights from mosquito surveillance in Chengdu, China

Frontiers in Cellular and Infection Microbiology
ObjectivesThis study aimed to investigate the spatiotemporal distribution of mosquito density and its associations with meteorological factors in Chengdu, China, and to compare the predictive performance of different models, thereby providing a ...
Shuwei Pei, Wei Zhang, Dan Kuang, Chunxia Luo, Wenjia Tian, Shuangfeng Fan   +5 more
doaj   +1 more source

Disinfection [PDF]

, 2018
Disinfection is a method used to destroy most microbial forms, especially vegetative pathogens, by using physical and chemical procedures such as chlorination, UV radiation, boiling, vapor, etc.

core   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Multiple Cross Displacement Amplification Coupled With Gold Nanoparticles-Based Lateral Flow Biosensor for Detection of the Mobilized Colistin Resistance Gene mcr-1

Frontiers in Cellular and Infection Microbiology, 2019
Fast dissemination of the mobilized colistin resistance (mcr) gene mcr-1 in Enterobacteriaceae causes a huge threat to the treatment of severe infection. In the current report, a multiple cross displacement amplification (MCDA) coupled with the detection
Lin Gong, Ernan Liu, Jie Che, Juan Li, Xiaoli Liu, Huiqiong Xu, Jiansheng Liang   +6 more
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Insecticidal contact toxicity of several essential oils against stored product pests

Julius-Kühn-Archiv, 2018
Results of laboratory bioassays in Petri dishes on evaluation of contact toxicity of Illicium verum, Artemisia absinthium and Abies sibirica essential oils (EOs) against larvae of khapra beetle, Trogoderma granarium Ev., adults of grain weevil ...
Iakovlev, Petr A.
doaj   +1 more source