Results 61 to 70 of about 139,259 (310)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Filamentous surface structures drive biofilm formation in ICU-isolated Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus: implications for persistent environmental contamination

Microbiology Spectrum
The relationship between surface biofilms and the persistent contamination of environmental surfaces has garnered increasing attention. Although biofilm research is extensive, systematic comparisons of the morphological characteristics of pathogens ...
Bing Wang, Kaiwen Ni, Weiran Wang, Min Lu, Hui Jin   +4 more
doaj   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Viral hepatitis as co-infection. Of the past to the present and future

Журнал инфектологии, 2014
Chronic virus hepatitises and tuberculosis are widespread in the population as monoinfections that is caused by action of biological, social and economic factors of risk.
V. Yu. Nazarov, V. V. Nechaev, A. K. Ivanov, L. N. Pozhidaeva, T. V. Solomay, A. Sakra   +5 more
doaj   +1 more source

Evaluation of effectiveness of photosensitizers used in laser endodontics disinfection: A systematic review

, 2021
Photo-activated disinfection using photosensitizers has been proposed as an adjunct to conventional endodontic therapy for additional disinfection and improved treatment outcomes.
Roy George, Figueredo, Carlos Marcelo, Sin, Jonathan Hong‐Man, George, Roy, Carlos Marcelo Figueredo, Laurence J. Walsh, Jonathan Hong‐Man Sin, Walsh, Laurence J   +7 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Insecticide resistance in the field populations of the Asian tiger mosquito Aedes albopictus in Beijing: resistance status and associated detoxification genes

Frontiers in Physiology
BackgroundAedes (Stegomyia) albopictus (Skuse) is an invasive and widespread mosquito species that can transmit dengue, chikungunya, yellow fever, and Zika viruses. Its control heavily relies on the use of insecticides.
Xiaojie Zhou, Jing Li, Ruoyao Ni, Xinghui Qiu, Yong Zhang, Ying Tong   +5 more
doaj   +1 more source

Disinfection of Burkholderia pseudomallei in potable water

, 2005
The effect of chlorine, monochloramine and UV disinfection on the water-borne pathogen Burkholderia pseudomallei was assessed. Persistence of B. pseudomallei was verified by MPN involving a one-step recovery procedure.
Howard, K., Inglis, T.J.J.
core  

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Spatial Features of HFRS Morbidity in Territory of Republic Bashkortostan in 2010 - 2015

Эпидемиология и вакцинопрофилактика, 2017
Introduction. The main aim of the study is to identify the territories in the Republic of Bashkortostan and the categories of residents at high risk of HFRS infection for determining the directions of preventive measures. Materials and methods.
P. A. Mochalkin, A. P. Mochalkin, E. G. Stepanov, L. A. Farvazova, N. V. Popov   +4 more
doaj   +1 more source